Dendritic cell:extracellular Dendritic cell:extracellular 1.0 -1.0 *Histamine extracellular region 1.0 -1.0 IFNG 1.0 -1.0 *LPS extracellular region 1.0 -1.0 **TLR ligands 1.0 -1.0 *Flagellin 1.0 -1.0 *Resiquimod extracellular region 1.0 -1.0 **Autophosphorylation 1.0 -1.0 TNF 1.0 -1.0 TSLP Dendritic cell:membrane Dendritic cell:membrane 1.0 -1.0 FCER1A; FCER1G; MS4A2 1.0 -1.0 GRB2 1.0 -1.0 LAT 1.0 -1.0 HRH1 1.0 -1.0 HRH2 1.0 -1.0 HRH3 1.0 -1.0 HRH4 1.0 -1.0 IFNGR1; IFNGR2 1.0 -1.0 CD14 1.0 -1.0 TLR4 1.0 -1.0 LY96 1.0 -1.0 TLR5 1.0 -1.0 KDR 1.0 -1.0 TNFRSF1B 1.0 -1.0 CRLF2; IL7R Dendritic cell:cytosol Dendritic cell:cytosol 1.0 -1.0 **Arachnoid acid production 1.0 -1.0 *1,2-Diacyglycerol 1.0 -1.0 PRKCQ 1.0 -1.0 AKT1; AKT2; AKT3 1.0 -1.0 **AKT signaling 1.0 -1.0 BLNK 1.0 -1.0 PLCG1; PLCG2 1.0 -1.0 SYK 1.0 -1.0 BTK 1.0 -1.0 *Ca('2+) 1.0 -1.0 CALM1; CALM2; CALM3 1.0 -1.0 PPP3CA; PPP3CB; PPP3CC 1.0 -1.0 PLA2G4A; PLA2G4C 1.0 -1.0 LYN 1.0 -1.0 FER 1.0 -1.0 MAP2K3 1.0 -1.0 MAP2K6 1.0 -1.0 GAB2 1.0 -1.0 PIK3R1; PIK3R2; PIK3R3 1.0 -1.0 SOS1;SOS2 1.0 -1.0 LCP2 1.0 -1.0 HRAS 1.0 -1.0 RAF1 1.0 -1.0 CHUK; IKBKB 1.0 -1.0 IKBKG 1.0 -1.0 *IP3 1.0 -1.0 IGHE;IGHJ1;IGHJ2;IGHJ3; IGHJ4;IGHJ5;IGHJ6;IGK; IGKC;IGKJ@;IGKV@;IGL;IGLJ@;IGLV@ 1.0 -1.0 MAPK10; MAPK8; MAPK9 1.0 -1.0 MAP2K1; MAP2K2 1.0 -1.0 MAPK14;MAPK11;MAPK13;MAPK12 1.0 -1.0 MAP2K4 1.0 -1.0 MAP3K1 1.0 -1.0 MAP2K7 1.0 -1.0 PAK2 1.0 -1.0 PIK3CA; PIK3CB; PIK3CD 1.0 -1.0 *PtdIns(3,4,5)P3 1.0 -1.0 *PtdIns(4,5)P2 1.0 -1.0 RAC1 1.0 -1.0 VAV1 1.0 -1.0 **Histamine H1 receptor signaling in immune response 1.0 -1.0 **Immunological synapse formation 1.0 -1.0 CD86 1.0 -1.0 PRKCA 1.0 -1.0 ADCY1;ADCY2;ADCY3; ADCY4;ADCY5;ADCY6; ADCY7;ADCY8;ADCY9 1.0 -1.0 *Cyclic AMP 1.0 -1.0 *Pyrophosphate 1.0 -1.0 CCL2 1.0 -1.0 **Chemotaxis 1.0 -1.0 CCL5 1.0 -1.0 IL10 1.0 -1.0 TNF 1.0 -1.0 PRKAR1A; PRKAR1B; PRKAR2A;PRKAR2B 1.0 -1.0 MAPK1; MAPK3 1.0 -1.0 GNAI1;GNAI2; GNAI3;GNAO1; GNAZ 1.0 -1.0 GNB1;GNB2;GNB3;GNB4;GNB5; GNG10;GNG11;GNG12;GNG13; GNG2;GNG3;GNG4;GNG5; GNG7;GNG8;GNGT1;GNGT2 1.0 -1.0 GNA11;GNAQ 1.0 -1.0 PLCB1; PLCB2; PLCB3;PLCB4 1.0 -1.0 GNAS 1.0 -1.0 **Dendritic cell migration 1.0 -1.0 IL1B 1.0 -1.0 **Proinflammatory response 1.0 -1.0 **Anti- inflammatory response 1.0 -1.0 IL12B 1.0 -1.0 **Th1 cell development 1.0 -1.0 IL6 1.0 -1.0 CXCL8 1.0 -1.0 CCL3 1.0 -1.0 CCL4; CCL4L1 1.0 -1.0 PRKACA; PRKACB; PRKACG 1.0 -1.0 **ATM/ART regulation of G1/S checkpoint 1.0 -1.0 **Cell cycle regulation 1.0 -1.0 **Regulation of EIF2 activity 1.0 -1.0 **Regulation of translation 1.0 -1.0 **Regulation of EIF4F activity 1.0 -1.0 PRKCD 1.0 -1.0 AFAP1 1.0 -1.0 SRC 1.0 -1.0 RAPGEF1 1.0 -1.0 RAP1A 1.0 -1.0 CAMK2A; CAMK2B; CAMK2D;CAMK2G 1.0 -1.0 CRKL 1.0 -1.0 FANCC 1.0 -1.0 ICAM1 1.0 -1.0 **Cell adhesion 1.0 -1.0 JAK1 1.0 -1.0 JAK2 1.0 -1.0 CBL 1.0 -1.0 SOCS1 1.0 -1.0 EIF2AK2 1.0 -1.0 CDKN1A 1.0 -1.0 PTK2B 1.0 -1.0 MAP3K4 1.0 -1.0 PDPK1 1.0 -1.0 **Inhibition of cell proliferation 1.0 -1.0 PTPN11 1.0 -1.0 **TGF-beta receptor signaling 1.0 -1.0 **IL-1 signaling pathway 1.0 -1.0 **Inflammatory response 1.0 -1.0 **IL-10 signaling pathway 1.0 -1.0 **IL-12 signaling pathway 1.0 -1.0 **IL-8 dependent cell migration and adhesion 1.0 -1.0 **Inhibitory action of Lipoxins on pro-inflammatory NTNF-alpha signaling 1.0 -1.0 **NO production 1.0 -1.0 **NO synthesis and signaling 1.0 -1.0 **Production of prostaglandins 1.0 -1.0 **Prostaglandin 2 biosynthesis and metabolism 1.0 -1.0 PTGS2 1.0 -1.0 NOS2 1.0 -1.0 UBE2N 1.0 -1.0 MAP3K7 1.0 -1.0 TRAF6 1.0 -1.0 UBB;UBC 1.0 -1.0 RPS6KA4; RPS6KA5 1.0 -1.0 RPS6KA1; RPS6KA2; RPS6KA3 1.0 -1.0 **Il-6 signaling pathway 1.0 -1.0 IRAK1 1.0 -1.0 PELI1 1.0 -1.0 PELI2 1.0 -1.0 PELI3 1.0 -1.0 IRAK2 1.0 -1.0 IRAK4 1.0 -1.0 MYD88 1.0 -1.0 MAP3K8 1.0 -1.0 MAP3K14 1.0 -1.0 TAB1 1.0 -1.0 TAB2 1.0 -1.0 TAB3 1.0 -1.0 TIRAP 1.0 -1.0 **TLR3 and TLR4 induce TICAM1-specific signaling pathway 1.0 -1.0 UBE2V1 1.0 -1.0 **Antiviral actions of Interferons 1.0 -1.0 **Antiviral response 1.0 -1.0 **IL-6 signaling pathway 1.0 -1.0 **IL-8-dependent cell migration and adhesion 1.0 -1.0 **Inhibitory action of Lipoxins on pro-inflammatory TNF-alpha signaling 1.0 -1.0 TLR7 1.0 -1.0 TLR8 1.0 -1.0 TLR9 1.0 -1.0 RELA;REL; NFKB1;RELB; NFKB2 1.0 -1.0 IFNA1;IFNA10;IFNA13;IFNA14; IFNA16;IFNA17;IFNA2;IFNA21; IFNA4;IFNA5;IFNA6;IFNA7;IFNA8 1.0 -1.0 IFNB1 1.0 -1.0 *Unmethylated CpG DNA intracellular 1.0 -1.0 *Virus ssRNA extracellular region 1.0 -1.0 **Endothelial cell migration 1.0 -1.0 **Angiogenesis 1.0 -1.0 DAB2IP 1.0 -1.0 MAP3K5 1.0 -1.0 TRAF2 1.0 -1.0 ATF2 1.0 -1.0 **Cell proliferation 1.0 -1.0 **Regulation of apoptosis 1.0 -1.0 **Apoptosis 1.0 -1.0 BMX 1.0 -1.0 **Immune response 1.0 -1.0 SMURF2 1.0 -1.0 TRAF1 1.0 -1.0 TRAF3 1.0 -1.0 BIRC2 1.0 -1.0 BIRC3 1.0 -1.0 ZFP91 1.0 -1.0 **Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 1.0 -1.0 **CCL2-induced chemotaxis 1.0 -1.0 **Regulation of chemotaxis 1.0 -1.0 **CCR3 signaling in eosinophil 1.0 -1.0 **CCR4-induced chemotaxis of immune cells 1.0 -1.0 **IL-4 signaling pathway 1.0 -1.0 **Regulation of apoptosis by mitochondrial proteins 1.0 -1.0 **Anti- apoptosis 1.0 -1.0 **Regulation of tight junction assembly 1.0 -1.0 BCL2 1.0 -1.0 CCL17 1.0 -1.0 CISH 1.0 -1.0 CLDN7 1.0 -1.0 CCL11 1.0 -1.0 NFKBIA 1.0 -1.0 IL4 1.0 -1.0 TNFSF4 Dendritic cell:endoplasmic reticulum Dendritic cell:endoplasmic reticulum 1.0 -1.0 *Ca('2+) 1.0 -1.0 ITPR1; ITPR2; ITPR3 Dendritic cell:mitochondria Dendritic cell:mitochondria 1.0 -1.0 BMF 1.0 -1.0 BCL2 1.0 -1.0 BCL2L1 1.0 -1.0 BCL2L11 Dendritic cell:nucleus Dendritic cell:nucleus 1.0 -1.0 NFATC4 1.0 -1.0 MAPK1;MAPK3 1.0 -1.0 ELK1 1.0 -1.0 NFKBIA; NFKBIB; NFKBIE 1.0 -1.0 RELA;REL; NFKB1; RELB;NFKB2 1.0 -1.0 FOS;ATF2; FOSB;JUN;FOSL1; JUND;FOSL2;JUNB 1.0 -1.0 CREB1 1.0 -1.0 CREM 1.0 -1.0 NFATC2 1.0 -1.0 NFATC1 1.0 -1.0 IRF8 1.0 -1.0 BRCA1 1.0 -1.0 STAT1;STAT2;IRF9 1.0 -1.0 CEBPB 1.0 -1.0 CREBBP 1.0 -1.0 IRF1 1.0 -1.0 SMAD7 1.0 -1.0 MYC 1.0 -1.0 MCM5 1.0 -1.0 EP300 1.0 -1.0 IRF5 1.0 -1.0 IRF7 1.0 -1.0 STAT3 1.0 -1.0 STAT5A;STAT5B 1.0 -1.0 STAT6 1.0 -1.0 STAT4