Airway epithelial cell:extracellular Airway epithelial cell:extracellular 1.0 -1.0 **Activation of dendritic cells 1.0 -1.0 **Inflammation in asthma 1.0 -1.0 **Eosinophil accumulation in asthma 1.0 -1.0 **Inflammatory factors-induced expression of mucins and asthmatic epithelium 1.0 -1.0 **Neutrophil accumulation in asthma 1.0 -1.0 **Proteases and EGFR-induced mucin synthesis in normal and asthmatic airway epithelium 1.0 -1.0 **Regulation of Th2 balance in asthma 1.0 -1.0 CCL5 1.0 -1.0 CXCL16 1.0 -1.0 **Chemotaxis of Bonzo- expressing cells 1.0 -1.0 CCL11 1.0 -1.0 CCL26 1.0 -1.0 FN1 1.0 -1.0 **Disruption of epithelial layer restitution in asthma 1.0 -1.0 CXCL11 1.0 -1.0 IFNA1; IFNA10; IFNA13 1.0 -1.0 IFNG 1.0 -1.0 CCL17 1.0 -1.0 IL6 1.0 -1.0 CXCL8 1.0 -1.0 IL13RA2 1.0 -1.0 CXCL10 1.0 -1.0 CXCL9 1.0 -1.0 IL13 1.0 -1.0 IGF1 1.0 -1.0 IL4 1.0 -1.0 **Interleukins-induced inflammatory signaling in normal and asthmatic airway epithelium 1.0 -1.0 **TNF-alpha-induced inflammatory signaling in normal and asthmatic airway epithelium 1.0 -1.0 TSLP 1.0 -1.0 **Disruption of apoptosis, proliferation and shedding of epithelial cells in asthma 1.0 -1.0 CRLF2; IL7R 1.0 -1.0 **Proteases and EGFR-induced mucin synthesis in normal and asthmatic epithelium 1.0 -1.0 **Increased survival 1.0 -1.0 **Netrophil accumulation in asthma 1.0 -1.0 **Inflammation 1.0 -1.0 CXCL5 1.0 -1.0 CXCL1 1.0 -1.0 IL11 1.0 -1.0 CSF2 1.0 -1.0 CSF3 1.0 -1.0 CXCL6 1.0 -1.0 **Increase survival and accumulation of neutrophil, eosinophils, dendritic cells 1.0 -1.0 IL17A 1.0 -1.0 IL17F 1.0 -1.0 IL19 1.0 -1.0 **Inflammatory factors-induced expression of mucins in normal and asthmatic epithelium 1.0 -1.0 BMP4 1.0 -1.0 TGFB1 1.0 -1.0 IL1B 1.0 -1.0 TNF 1.0 -1.0 **Dendritic cell activation 1.0 -1.0 **Interkleukins-induced inflammatory signaling in normal and asthmatic airway epithelium 1.0 -1.0 **Leukocyte chemotaxis 1.0 -1.0 IL5 1.0 -1.0 CCL2 1.0 -1.0 TNFSF12; TNFSF12-TNFSF13 Airway epithelial cell:membrane Airway epithelial cell:membrane 1.0 -1.0 IL2RG; IL4R; IL13RA1 1.0 -1.0 ICAM1 1.0 -1.0 IFNGR1; IFNGR2 1.0 -1.0 IL1RL1 1.0 -1.0 IL17RA 1.0 -1.0 IL17RC 1.0 -1.0 TGFBR1 1.0 -1.0 TGFBR2 1.0 -1.0 TNFRSF12A 1.0 -1.0 TNFRSF1A Airway epithelial cell:cytosol Airway epithelial cell:cytosol 1.0 -1.0 **IFN-gamma signaling pathways 1.0 -1.0 MAPK1; MAPK3 1.0 -1.0 MAPK10; MAPK8; MAPK9 1.0 -1.0 **IL-4 signaling pathway 1.0 -1.0 **Leukocyte chemotaxis 1.0 -1.0 CCL2 1.0 -1.0 MAPK14; MAPK11; MAPK13; MAPK12 1.0 -1.0 **IL-17 signaling pathways 1.0 -1.0 CHUK;IKBKB 1.0 -1.0 RPS6KA5 1.0 -1.0 RPS6KA1; RPS6KA2; RPS6KA3 1.0 -1.0 MAP2K1 1.0 -1.0 MAP2K2 1.0 -1.0 RAF1 1.0 -1.0 **Cell migration 1.0 -1.0 **Wound healing 1.0 -1.0 **Epithelial to mesenchymal transition (EMT) 1.0 -1.0 **Lowering of the transepithelial resistance 1.0 -1.0 **NOTCH- induced EMT 1.0 -1.0 JAG1 1.0 -1.0 **TGF-beta-dependent induction of EMT via MAPK 1.0 -1.0 ACTA2 1.0 -1.0 CD44 1.0 -1.0 COL1A1 1.0 -1.0 CTGF 1.0 -1.0 DAB2 1.0 -1.0 MAP3K7 1.0 -1.0 CDH1 1.0 -1.0 **Disruption of apoptosis, proliferation and shedding of epithelial cells in asthma 1.0 -1.0 TNC 1.0 -1.0 FN1 1.0 -1.0 **Disruption of epithelial layer restitution in asthma 1.0 -1.0 MMP9 1.0 -1.0 ITGB3 1.0 -1.0 MAP2K4 1.0 -1.0 MAP2K7 1.0 -1.0 MMP2 1.0 -1.0 CDH2 1.0 -1.0 SERPINE1 1.0 -1.0 OCLN 1.0 -1.0 SMAD7 1.0 -1.0 VIM 1.0 -1.0 DDR1 1.0 -1.0 SCGB1A1 1.0 -1.0 TJP1 1.0 -1.0 **Ceramides signaling pathway 1.0 -1.0 *Ceramides 1.0 -1.0 **IFN-gamma and Th2 cytokines-induced inflammatory signaling in normal and asthmatic airway epithelium 1.0 -1.0 **TNF-R1 signaling pathway 1.0 -1.0 MAP3K1 1.0 -1.0 PPP2CA; PPP2CB 1.0 -1.0 HRAS 1.0 -1.0 NFKBIB; NFKBIE; NFKBIA 1.0 -1.0 TNF Airway epithelial cell:nucleus Airway epithelial cell:nucleus 1.0 -1.0 IRF1 1.0 -1.0 **IL-13 signaling via PI3K-ERK 1.0 -1.0 RELA;REL; NFKB1;RELB; NFKB2 1.0 -1.0 STAT6 1.0 -1.0 SOCS3 1.0 -1.0 JAK2 1.0 -1.0 SOCS1 1.0 -1.0 STAT1 1.0 -1.0 CREB1 1.0 -1.0 NFKBIA; NFKBIB; NFKBIE 1.0 -1.0 ETS1 1.0 -1.0 HMGA2 1.0 -1.0 SNAI2 1.0 -1.0 SNAI1 1.0 -1.0 TWIST1 1.0 -1.0 SMAD2 1.0 -1.0 SMAD3 1.0 -1.0 FOS;ATF2;FOSB; JUN;FOSL1;JUND; FOSL2;JUNB 1.0 -1.0 SP1 1.0 -1.0 SMAD4 1.0 -1.0 **Anti-apoptotic TNFs/NF-kB/Bcl-3 pathway 1.0 -1.0 MAPK1; MAPK3 T cell:membrane T cell:membrane 1.0 -1.0 CXCR6 Leukocyte:membrane Leukocyte:membrane 1.0 -1.0 CXCR3 Leukocyte:cytosol Leukocyte:cytosol 1.0 -1.0 **Leukocyte chemotaxis