Th0:extracellular Th0:extracellular 1.0 -1.0 **CTLA-4 regulation of T cell function 1.0 -1.0 IFNG 1.0 -1.0 IL12A; IL12B 1.0 -1.0 **Antigen presentation by MHC class I 1.0 -1.0 **Antigen presentation by MHC class II 1.0 -1.0 **Antigen stimulation 1.0 -1.0 IL18 1.0 -1.0 IL13 1.0 -1.0 MMP8 1.0 -1.0 IL15 1.0 -1.0 IL6 1.0 -1.0 CXCL8 1.0 -1.0 **IL-15 signaling 1.0 -1.0 IL2RG;IL15RA; IL4R;IL2RB 1.0 -1.0 ADAM17 1.0 -1.0 **IL-12-induced IFN-gamma production 1.0 -1.0 IL18R1 1.0 -1.0 **IL2 activation and signaling pathway 1.0 -1.0 **Inhibition of CD4-positive T cell proliferation 1.0 -1.0 IL10 1.0 -1.0 **Inhibition of immune response 1.0 -1.0 EBI3;IL27 1.0 -1.0 IL2 1.0 -1.0 IL4 1.0 -1.0 IL1A Th0:membrane Th0:membrane 1.0 -1.0 CD28 1.0 -1.0 CD247;CD3D; CD3E;CD3G 1.0 -1.0 CD80 1.0 -1.0 CD86 1.0 -1.0 LAT 1.0 -1.0 TRAC;TRAJ18;TRAV24; TRB;TRBV11-1;TRBV11-2; TRBV11-3;TRBV17 1.0 -1.0 IFNGR1; IFNGR2 1.0 -1.0 IL12RB2; IL12RB1 1.0 -1.0 IL18R1 1.0 -1.0 IL2RG; IL4R; IL13RA1 1.0 -1.0 IL13RA2 1.0 -1.0 ADAM17 1.0 -1.0 GRB2 1.0 -1.0 **Th1 cell differentiation 1.0 -1.0 IL18RAP 1.0 -1.0 IL27RA;IL6R; IL6ST 1.0 -1.0 ADAM10 1.0 -1.0 IL1R1 1.0 -1.0 IL1RAP 1.0 -1.0 CD4 1.0 -1.0 HLA-DMA;HLA-DMB;HLA-DOA; HLA-DOB;HLA-DPA1;HLA-DPB1; HLA-DPB2;HLA-DQA1;HLA-DQA2; HLA-DQB1;HLA-DQB2;HLA-DQB3; HLA-DRA;HLA-DRB1;HLA-DRB3; HLA-DRB4;HLA-DRB5;LOC100509457 Th0:cytosol Th0:cytosol 1.0 -1.0 **Regulation of actin cytoskeleton by Rho GTPases 1.0 -1.0 **Cytoskeleton remodeling 1.0 -1.0 *1,2-Diacyglycerol 1.0 -1.0 PRKCQ 1.0 -1.0 AKT1;AKT2;AKT3 1.0 -1.0 BAD 1.0 -1.0 GSK3B 1.0 -1.0 CHUK;IKBKB 1.0 -1.0 **Cell survival 1.0 -1.0 GRAP2 1.0 -1.0 GRB2 1.0 -1.0 ITK 1.0 -1.0 PIK3R2;PIK3R1; PIK3R3 1.0 -1.0 ZAP70 1.0 -1.0 *Ca('2+) 1.0 -1.0 CALM1;CALM2; CALM3 1.0 -1.0 PPP3CA;PPP3CB; PPP3CC 1.0 -1.0 FYN 1.0 -1.0 VAV1 1.0 -1.0 LCP2 1.0 -1.0 IKBKG 1.0 -1.0 *IP3 1.0 -1.0 PLCG1 1.0 -1.0 MAPK10;MAPK8; MAPK9 1.0 -1.0 MAP2K4 1.0 -1.0 MAP3K1 1.0 -1.0 MAP2K7 1.0 -1.0 PAK1 1.0 -1.0 MAPK14;MAPK11; MAPK13;MAPK12 1.0 -1.0 PIK3CB;PIK3CD; PIK3CA 1.0 -1.0 *PtdIns(3,4,5)P3 1.0 -1.0 PIP5K1A;PIP5K1B; PIP5K1C 1.0 -1.0 *PtdIns(4,5)P2 1.0 -1.0 *Phosphatidylinositol 4-phosphate 1.0 -1.0 RAC1 1.0 -1.0 **Cell proliferation 1.0 -1.0 **Immune response 1.0 -1.0 **ATM/ART regulation of G1/S checkpoint 1.0 -1.0 **Cell cycle regulation 1.0 -1.0 **Regulation of EIF2 activity 1.0 -1.0 **Regulation of translation 1.0 -1.0 **Regulation of EIF4F activity 1.0 -1.0 PRKCA 1.0 -1.0 PRKCD 1.0 -1.0 AFAP1 1.0 -1.0 SRC 1.0 -1.0 RAPGEF1 1.0 -1.0 RAP1A 1.0 -1.0 CAMK2A;CAMK2B; CAMK2D;CAMK2G 1.0 -1.0 CRKL 1.0 -1.0 MAPK1; MAPK3 1.0 -1.0 FANCC 1.0 -1.0 ICAM1 1.0 -1.0 **Cell adhesion 1.0 -1.0 JAK1 1.0 -1.0 JAK2 1.0 -1.0 CBL 1.0 -1.0 SOCS1 1.0 -1.0 EIF2AK2 1.0 -1.0 CDKN1A 1.0 -1.0 PLCG2 1.0 -1.0 PTK2B 1.0 -1.0 MAP2K6 1.0 -1.0 MAP3K4 1.0 -1.0 PDPK1 1.0 -1.0 **Inhibition of cell proliferation 1.0 -1.0 PTPN11 1.0 -1.0 **TGF-beta receptor signaling 1.0 -1.0 **IL-12-induced IFN-gamma production 1.0 -1.0 IFNG 1.0 -1.0 **IL2 activation and signaling pathway 1.0 -1.0 **T cell proliferation 1.0 -1.0 GCNT1 1.0 -1.0 *P-selectin 1.0 -1.0 **IFN gamma signaling pathway 1.0 -1.0 **T-helper 1 cell differentiation 1.0 -1.0 TYK2 1.0 -1.0 IL18R1 1.0 -1.0 IL2RA 1.0 -1.0 IRF1 1.0 -1.0 IRF4 1.0 -1.0 STAT5B;STAT5A 1.0 -1.0 PDLIM2 1.0 -1.0 UBB;UBC 1.0 -1.0 PIAS2 1.0 -1.0 PRF1 1.0 -1.0 **Natural killer cell mediated cytotoxicity 1.0 -1.0 SOCS3 1.0 -1.0 **Th1 and Th2 cell differentiation 1.0 -1.0 **T-helper 1 and cell activation 1.0 -1.0 CD247;CD3D; CD3E;CD3G 1.0 -1.0 GADD45G 1.0 -1.0 GADD45B 1.0 -1.0 NOS2 1.0 -1.0 IRAK2;IRAK1 1.0 -1.0 TRAF6 1.0 -1.0 *L-Arginine 1.0 -1.0 *L-Citrulline 1.0 -1.0 *NO 1.0 -1.0 MAP2K3 1.0 -1.0 MAP3K14 1.0 -1.0 *O(,2) 1.0 -1.0 **JNK(MAPK8-10) 1.0 -1.0 *AKT(PKB) 1.0 -1.0 **T cell survival 1.0 -1.0 CCND3 1.0 -1.0 NFKBIZ 1.0 -1.0 IL12A;IL12B 1.0 -1.0 LCK 1.0 -1.0 SPHK2 1.0 -1.0 MTOR 1.0 -1.0 **No synthesis and signaling 1.0 -1.0 **Inhibition of NO mediated signal transduction 1.0 -1.0 ALOX15 1.0 -1.0 **Inflammation 1.0 -1.0 ARG1 1.0 -1.0 *L-Ornithine 1.0 -1.0 *Urea 1.0 -1.0 CCL17 1.0 -1.0 CCL23 1.0 -1.0 FCER2 1.0 -1.0 COL1A2 1.0 -1.0 **Fibrosis 1.0 -1.0 *Chitinase 3L3 1.0 -1.0 CCL11 1.0 -1.0 CCL26 1.0 -1.0 HSD3B1 1.0 -1.0 **Steroid Hormone synthesis 1.0 -1.0 IGHE 1.0 -1.0 IGHG4 1.0 -1.0 IL1RN 1.0 -1.0 RETNLB 1.0 -1.0 **Myofibroblast differentiation 1.0 -1.0 SERPINB3 1.0 -1.0 SERPINB4 1.0 -1.0 PTPN6 1.0 -1.0 SPRR2B 1.0 -1.0 CCL2 1.0 -1.0 *Chitinase 3L3 1.0 -1.0 FOXJ1 1.0 -1.0 SCGB3A1 1.0 -1.0 PRKCE 1.0 -1.0 **Smooth muscle contraction 1.0 -1.0 *Tenascin-C 1.0 -1.0 ADCY1 1.0 -1.0 *Cyclic AMP 1.0 -1.0 *Pyrophosphate 1.0 -1.0 **Inhibition of oxygen and reactive oxygen species p roduction 1.0 -1.0 *HCO(,3)('-) 1.0 -1.0 *Putrescine 1.0 -1.0 SPHK1 1.0 -1.0 SOS1;SOS2 1.0 -1.0 HRAS 1.0 -1.0 RAF1 1.0 -1.0 IGHE 1.0 -1.0 IRS1 1.0 -1.0 IRS2 1.0 -1.0 MAP2K1;MAP2K2 1.0 -1.0 PRKCZ 1.0 -1.0 **Intestinal epithelial permeability 1.0 -1.0 MUC5AC 1.0 -1.0 EIF4EBP1 1.0 -1.0 EIF4E 1.0 -1.0 IL2RB;IL2RG; IL15RA 1.0 -1.0 MKNK1 1.0 -1.0 PLCB1 1.0 -1.0 MYB 1.0 -1.0 FKBP1A 1.0 -1.0 RPTOR 1.0 -1.0 GAB2 1.0 -1.0 PTK2 1.0 -1.0 RAC3 1.0 -1.0 SHC1 1.0 -1.0 SYK 1.0 -1.0 TRAF2 1.0 -1.0 AXL 1.0 -1.0 RPS6KB1 1.0 -1.0 RPS6KB2 1.0 -1.0 **IL-4 signaling pathway 1.0 -1.0 **Th2 cell differentiation 1.0 -1.0 BCL2 1.0 -1.0 **Anti-apoptosis 1.0 -1.0 BCL2L1 1.0 -1.0 IL4 1.0 -1.0 STAT2 1.0 -1.0 MCL1 1.0 -1.0 **CCL2 signaling 1.0 -1.0 **Cell migration 1.0 -1.0 **FAS signaling cascades 1.0 -1.0 **Cytotoxicity 1.0 -1.0 **Fibronectin-binding integrins in cell motility 1.0 -1.0 **Adhesion 1.0 -1.0 **IL-1 signaling pathway 1.0 -1.0 **IL-6 signaling pathway 1.0 -1.0 **IL-8 dependent cell migration and adhesion 1.0 -1.0 **Inhibitory action of Lipoxins on pro-inflammatory TNF-alpha signaling 1.0 -1.0 **Regulation of Apoptosis by Mitochondrial Proteins 1.0 -1.0 **Apoptosis 1.0 -1.0 CXCL16 1.0 -1.0 SELE 1.0 -1.0 IL1A 1.0 -1.0 IL6 1.0 -1.0 CXCL8 1.0 -1.0 MMP9 1.0 -1.0 VCAM1 1.0 -1.0 BSG 1.0 -1.0 PTGS2 1.0 -1.0 **Proliferation 1.0 -1.0 FASLG 1.0 -1.0 FN1 1.0 -1.0 CYBA 1.0 -1.0 **Oxidative burst 1.0 -1.0 *IL-1 alpha 1.0 -1.0 IL1B 1.0 -1.0 MYD88 1.0 -1.0 TICAM2 1.0 -1.0 IRAK4 1.0 -1.0 TNF 1.0 -1.0 NCF1 1.0 -1.0 NCF2 1.0 -1.0 TAB1 1.0 -1.0 MAP3K7 1.0 -1.0 TAB2 1.0 -1.0 **Inhibitory action of Lipoxins on pro-inflammatory 1.0 -1.0 **TCR and CD28 co-stimulation in activation NF-kB 1.0 -1.0 PIM1 1.0 -1.0 **CD4-positive T cell proliferation 1.0 -1.0 MYC 1.0 -1.0 **Regulation of Apoptosis by Mithochondrial Proteins 1.0 -1.0 **Anti-Apoptosis 1.0 -1.0 RPS6KA1 1.0 -1.0 JAK3 1.0 -1.0 **Cell growth 1.0 -1.0 NFKBIA 1.0 -1.0 NFKBIB 1.0 -1.0 **AKT signaling 1.0 -1.0 FES 1.0 -1.0 INPP5D 1.0 -1.0 IGHG1 1.0 -1.0 SOCS5 1.0 -1.0 **Glucocorticoid signaling 1.0 -1.0 **IFN gamma signaling 1.0 -1.0 **IL-1 signaling 1.0 -1.0 NFKB1;NFKB2; REL;RELA;RELB 1.0 -1.0 **IL-6 and IL-1 signaling 1.0 -1.0 **MIF-mediated glucocorticoid regulation 1.0 -1.0 **TLR2 and TLR4 signaling 1.0 -1.0 **TLR5, TLR7, TLR8 and TLR8 singaling 1.0 -1.0 **TNF-alpha signaling 1.0 -1.0 JUND 1.0 -1.0 IKBKAP 1.0 -1.0 ECSIT 1.0 -1.0 BCL10 1.0 -1.0 UBE2N 1.0 -1.0 MALT1 1.0 -1.0 CARD11 1.0 -1.0 UBE2V2 Th0:endoplasmic reticulum Th0:endoplasmic reticulum 1.0 -1.0 *Ca('2+) 1.0 -1.0 ITPR1;ITPR2; ITPR3 Th0:mitochondria Th0:mitochondria 1.0 -1.0 BCL2L1 1.0 -1.0 BCL2 1.0 -1.0 MCL1 Th0:nucleus Th0:nucleus 1.0 -1.0 LCK 1.0 -1.0 NFATC2 1.0 -1.0 NFATC1 1.0 -1.0 NFATC4 1.0 -1.0 NFKBIA;NFKBIB; NFKBIE 1.0 -1.0 RELA;REL; NFKB1;RELB; NFKB2 1.0 -1.0 BRCA1 1.0 -1.0 STAT1;STAT2; IRF9 1.0 -1.0 CEBPB 1.0 -1.0 CREBBP 1.0 -1.0 IRF1 1.0 -1.0 SMAD7 1.0 -1.0 MYC 1.0 -1.0 MCM5 1.0 -1.0 EP300 1.0 -1.0 FOS;ATF2;FOSB; JUN;FOSL1;JUND; FOSL2;JUNB 1.0 -1.0 STAT4 1.0 -1.0 STAT3 1.0 -1.0 ETV5 1.0 -1.0 TBX21 1.0 -1.0 IFNG 1.0 -1.0 MAPK10;MAPK8; MAPK9 1.0 -1.0 PDLIM2 1.0 -1.0 RUNX3 1.0 -1.0 STAT5A; STAT5B 1.0 -1.0 STAT6 1.0 -1.0 SOCS1 1.0 -1.0 ODC1 1.0 -1.0 ELK1 1.0 -1.0 MAPK11;MAPK12; MAPK13;MAPK14 1.0 -1.0 JAK1 1.0 -1.0 JAK2 1.0 -1.0 JAK3 1.0 -1.0 SYK 1.0 -1.0 TYK2 1.0 -1.0 **T cell growth 1.0 -1.0 SP1 1.0 -1.0 GATA3 1.0 -1.0 NR3C1 1.0 -1.0 CEBPD 1.0 -1.0 CREB1 1.0 -1.0 SRF 1.0 -1.0 MAPK1;MAPK3