ILC precursor:extracellular ILC precursor:extracellular 1.0 -1.0 **ECM remodiling 1.0 -1.0 **Bone destruction 1.0 -1.0 **Osteoclast differentiation 1.0 -1.0 **Th17 cell differentiation 1.0 -1.0 IL17A 1.0 -1.0 IL6 1.0 -1.0 IL1B 1.0 -1.0 IL17F 1.0 -1.0 MMP1 1.0 -1.0 MMP9 1.0 -1.0 TNFSF11 1.0 -1.0 MMP3 1.0 -1.0 IL21 1.0 -1.0 IL12B;IL23A 1.0 -1.0 IL33 ILC precursor:membrane ILC precursor:membrane 1.0 -1.0 IL17RA 1.0 -1.0 IL17RC 1.0 -1.0 IL23R;IL12RB1 1.0 -1.0 IL1RL1 1.0 -1.0 IL1RAP ILC precursor:cytosol ILC precursor:cytosol 1.0 -1.0 **Chemokines and adhesion 1.0 -1.0 **Chemotaxis 1.0 -1.0 **GM-CSF signaling 1.0 -1.0 **Granulopoiesis 1.0 -1.0 **IL-6 signaling pathway 1.0 -1.0 **Inflammatory response 1.0 -1.0 **PGE2 synthesis 1.0 -1.0 **Prostaglandin 2 biosynthesis 1.0 -1.0 **Transcription regulation of granulocyte development 1.0 -1.0 AKT1;AKT2; AKT3 1.0 -1.0 GSK3B 1.0 -1.0 DEFB4A; DEFB4B 1.0 -1.0 **Antibacterial activity 1.0 -1.0 **Chemotaxis of CCR6-positive T cells 1.0 -1.0 **Chemotaxis of CCR6-positive dendritic cells 1.0 -1.0 CCL2 1.0 -1.0 CCL7 1.0 -1.0 LCN2 1.0 -1.0 PTGS2 1.0 -1.0 CCL20 1.0 -1.0 TRAF3IP2 1.0 -1.0 IKBKG 1.0 -1.0 MAP3K7 1.0 -1.0 TRAF6 1.0 -1.0 CXCL5 1.0 -1.0 **Neutrophil chemotaxis 1.0 -1.0 MAPK1; MAPK3 1.0 -1.0 CHUK;IKBKB 1.0 -1.0 JUN;FOS 1.0 -1.0 CSF3 1.0 -1.0 CXCL6 1.0 -1.0 CSF2 1.0 -1.0 CXCL1 1.0 -1.0 ICAM1 1.0 -1.0 **Cell adhesion 1.0 -1.0 JAK1 1.0 -1.0 JAK2 1.0 -1.0 MAP2K1;MAP2K2 1.0 -1.0 MUC5AC 1.0 -1.0 MUC5B 1.0 -1.0 CXCL8 1.0 -1.0 PIK3R1;PIK3R2; PIK3R3 1.0 -1.0 *L-Arginine 1.0 -1.0 *L-Citrulline 1.0 -1.0 *NO 1.0 -1.0 MAP2K3 1.0 -1.0 MAPK14;MAPK11; MAPK13;MAPK12 1.0 -1.0 MAP2K6 1.0 -1.0 NOS2 1.0 -1.0 MAP3K14 1.0 -1.0 *O(,2) 1.0 -1.0 PIK3CB;PIK3CD; PIK3CA 1.0 -1.0 *PtdIns(3,4,5)P3 1.0 -1.0 *PtdIns(4,5)P2 1.0 -1.0 TNFSF11 1.0 -1.0 **MAPK activation 1.0 -1.0 MAPK10; MAPK8; MAPK9 1.0 -1.0 **PTMs in IL-17-inducced CIKS-independent singaling pathway 1.0 -1.0 **PTMs in IL-17-induced CIKS-independent singaling pathway 1.0 -1.0 TNIP2 1.0 -1.0 MAP3K8 1.0 -1.0 **Regulation of gene expression 1.0 -1.0 TRAF2 1.0 -1.0 TRAF5 1.0 -1.0 UBB;UBC 1.0 -1.0 UBE2N 1.0 -1.0 **PTMs in IL-17-induced CIKS-dependent NF-kB signaling and mRNA stabilization 1.0 -1.0 RELA;REL;NFKB1; RELB;NFKB2 1.0 -1.0 IKBKE 1.0 -1.0 **PTMs in IL-17-induced CIKS-independent signaling pathway 1.0 -1.0 MAP3K3 1.0 -1.0 MAP2K4 1.0 -1.0 TAB1 1.0 -1.0 TAB2 1.0 -1.0 UBA1 1.0 -1.0 UBE2V1 1.0 -1.0 **mRNA stabilization 1.0 -1.0 TRAF4 1.0 -1.0 BTRC;CUL1; FBXW11;FBXW7; RBX1;SKP1;SKP2 1.0 -1.0 TRAF3 1.0 -1.0 SRSF1 1.0 -1.0 TBK1 1.0 -1.0 USP25 1.0 -1.0 **PTMs in IL-17-induced CIKS-dependent MAPK signaling pathways 1.0 -1.0 DUSP1 1.0 -1.0 MIR101-2; MIR101-1 1.0 -1.0 RPS6KA1; RPS6KA2; RPS6KA3 1.0 -1.0 JAK3 1.0 -1.0 TYK2 1.0 -1.0 RAF1 1.0 -1.0 STAT2 1.0 -1.0 PDPK1 1.0 -1.0 MAPKAPK2 1.0 -1.0 IL17A 1.0 -1.0 **Expandion and/or maintenance the Th17 cell population 1.0 -1.0 **IL-17 signaling pathway 1.0 -1.0 IL17F 1.0 -1.0 SOCS3 1.0 -1.0 NFKBIA 1.0 -1.0 SOCS1 1.0 -1.0 **IL-13 signaling via JAK-STAT 1.0 -1.0 **IL-13 signaling via PI3K-ERK 1.0 -1.0 **IL-5 signalling 1.0 -1.0 **IL-6 signalling pathway 1.0 -1.0 **IL-8 dependent cell migration and adhesion 1.0 -1.0 **Inhibitory action of Lipoxins on pro-inflammatory TNF-alpha signalling 1.0 -1.0 NOS3 1.0 -1.0 SELE 1.0 -1.0 RPS6KA5 1.0 -1.0 H2AFX;H2AFZ;HIST1H2AC; HIST1H2AD;HIST1H2AG; HIST1H2AI;HIST1H2AJ; HIST1H2AK;HIST1H2AL; HIST1H2AM;HIST2H2AC 1.0 -1.0 H2BFS;HIST1H2BB;HIST1H2BC;HIST1H2BD; HIST1H2BE;HIST1H2BF;HIST1H2BG; HIST1H2BH;HIST1H2BI;HIST1H2BJ; HIST1H2BL;HIST1H2BM;HIST1H2BN; HIST1H2BO;HIST2H2BE;LOC102724334 1.0 -1.0 IL13 1.0 -1.0 IL5 1.0 -1.0 IL6 1.0 -1.0 MYD88 1.0 -1.0 IRAK1 1.0 -1.0 IRAK4 1.0 -1.0 MAP2K7 1.0 -1.0 *N-omega- Hydroxy- L-arginine 1.0 -1.0 TNF 1.0 -1.0 VCAM1 1.0 -1.0 **Angiogenesis 1.0 -1.0 TMED1 ILC precursor:nucleus ILC precursor:nucleus 1.0 -1.0 CEBPB 1.0 -1.0 CEBPD 1.0 -1.0 SP1 1.0 -1.0 NFKBIA;NFKBIB; NFKBIE 1.0 -1.0 RELA;REL;NFKB1; RELB;NFKB2 1.0 -1.0 ATF2 1.0 -1.0 **Regulation of gene expression 1.0 -1.0 **Inhibition of gene expression 1.0 -1.0 ELK1 1.0 -1.0 FOS 1.0 -1.0 JUN 1.0 -1.0 FOSL1 1.0 -1.0 STAT1 1.0 -1.0 STAT3 1.0 -1.0 STAT4 1.0 -1.0 STAT5A; STAT5B 1.0 -1.0 RORC 1.0 -1.0 IL17A 1.0 -1.0 TNFSF11