B cell:extracellular B cell:extracellular 1.0 -1.0 IFNG 1.0 -1.0 IL13 1.0 -1.0 MMP8 1.0 -1.0 IL4 1.0 -1.0 IL2RG; IL4R B cell:membrane B cell:membrane 1.0 -1.0 CD19 1.0 -1.0 CR2 1.0 -1.0 CD22 1.0 -1.0 PTPRC 1.0 -1.0 CD79A;CD79B 1.0 -1.0 CD81 1.0 -1.0 FCGR2B 1.0 -1.0 IGHJ1;IGHJ2;IGHJ3;IGHJ4;IGHJ5;IGHJ6;IGHM;IGK;IGKC;IGKJ@;IGKV@;IGL;IGLJ@;IGLV@ 1.0 -1.0 CD40 1.0 -1.0 CD40LG 1.0 -1.0 *Sphingomyelin 1.0 -1.0 IFNGR1; IFNGR2 1.0 -1.0 IL2RG; IL4R; IL13RA1 1.0 -1.0 IL13RA2 B cell:cytosol B cell:cytosol 1.0 -1.0 **Ras family GTPases in kinase cascades 1.0 -1.0 MAPK1; MAPK3 1.0 -1.0 **Regulation activity of EIF4F 1.0 -1.0 **Translation 1.0 -1.0 **Regulation of Apoptosis by Mitochondrial Proteins 1.0 -1.0 **Anti-apoptosis 1.0 -1.0 *1,2-Diacyglycerol 1.0 -1.0 PRKCB 1.0 -1.0 AKT1; AKT2; AKT3 1.0 -1.0 BAD 1.0 -1.0 GSK3B 1.0 -1.0 BLNK 1.0 -1.0 PLCG1; PLCG2 1.0 -1.0 SYK 1.0 -1.0 BCL10 1.0 -1.0 IKBKG 1.0 -1.0 MAP3K7 1.0 -1.0 BTK 1.0 -1.0 CARD11 1.0 -1.0 MALT1 1.0 -1.0 PIK3R2;PIK3R1;PIK3R3 1.0 -1.0 VAV1 1.0 -1.0 VAV2 1.0 -1.0 PTPN6 1.0 -1.0 LYN 1.0 -1.0 CDC42 1.0 -1.0 **CDC42 in cellular processes 1.0 -1.0 *Ca('2+) 1.0 -1.0 CALM1; CALM2; CALM3 1.0 -1.0 PPP3CA; PPP3CB; PPP3CC 1.0 -1.0 INPP5D 1.0 -1.0 GRB2 1.0 -1.0 SOS1;SOS2 1.0 -1.0 HRAS 1.0 -1.0 CHUK;IKBKB 1.0 -1.0 *IP3 1.0 -1.0 PDPK1 1.0 -1.0 RPS6KB1 1.0 -1.0 PIK3CB; PIK3CD; PIK3CA 1.0 -1.0 *PtdIns(3,4,5)P3 1.0 -1.0 PTEN 1.0 -1.0 *PtdIns(4,5)P2 1.0 -1.0 *PtdIns(3,4)P2 1.0 -1.0 RAC1 1.0 -1.0 **RAC1 in cellular processes 1.0 -1.0 SHC1 1.0 -1.0 **Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 1.0 -1.0 **Cell survival 1.0 -1.0 **CD28 signaling 1.0 -1.0 **Immune response 1.0 -1.0 **Chemokines and adhesion 1.0 -1.0 **FAS signaling cascades 1.0 -1.0 **Apoptosis 1.0 -1.0 **IL-6 signaling pathway 1.0 -1.0 **Immunological synapse formation 1.0 -1.0 **Lymphotoxin-beta receptor signaling 1.0 -1.0 **Prostagladin 2 biosynthesis and metabolism FM 1.0 -1.0 **Regulation of G1/S translation 1.0 -1.0 **B cell proliferation 1.0 -1.0 **Regulation of G1/S translation 1.0 -1.0 TNFAIP3 1.0 -1.0 CCL2 1.0 -1.0 SMPD1 1.0 -1.0 *Choline phosphate 1.0 -1.0 *N-Acylsphingosine 1.0 -1.0 BCL2L1 1.0 -1.0 FCER2 1.0 -1.0 JAK2 1.0 -1.0 JAK3 1.0 -1.0 TRAF2 1.0 -1.0 TRAF3 1.0 -1.0 TRAF5 1.0 -1.0 TRAF6 1.0 -1.0 CBL 1.0 -1.0 TP53 1.0 -1.0 CD80 1.0 -1.0 CD86 1.0 -1.0 TRAF3IP2 1.0 -1.0 PTGS2 1.0 -1.0 *Ceramides cytoplasm 1.0 -1.0 CCND2 1.0 -1.0 FASLG 1.0 -1.0 FAS 1.0 -1.0 ICAM1 1.0 -1.0 **Germinal center formation 1.0 -1.0 IL6 1.0 -1.0 CXCL8 1.0 -1.0 STAT5A 1.0 -1.0 MAPK8 1.0 -1.0 MAPK9 1.0 -1.0 MAP2K3 1.0 -1.0 MAPK11; MAPK12; MAPK13;MAPK14 1.0 -1.0 MAP2K4 1.0 -1.0 MAP3K1 1.0 -1.0 RELA;RELB; NFKB2; NFKB1;REL 1.0 -1.0 CFLAR 1.0 -1.0 MAP3K14 1.0 -1.0 CDKN1B 1.0 -1.0 LTA 1.0 -1.0 TRAF1 1.0 -1.0 **ATM/ART regulation of G1/S checkpoint 1.0 -1.0 **Cell cycle regulation 1.0 -1.0 **Regulation of EIF2 activity 1.0 -1.0 **Regulation of translation 1.0 -1.0 **Regulation of EIF4F activity 1.0 -1.0 PRKCA 1.0 -1.0 PRKCD 1.0 -1.0 AFAP1 1.0 -1.0 SRC 1.0 -1.0 RAPGEF1 1.0 -1.0 RAP1A 1.0 -1.0 CAMK2A; CAMK2B; CAMK2D;CAMK2G 1.0 -1.0 CRKL 1.0 -1.0 FANCC 1.0 -1.0 **Cell adhesion 1.0 -1.0 JAK1 1.0 -1.0 SOCS1 1.0 -1.0 EIF2AK2 1.0 -1.0 CDKN1A 1.0 -1.0 PTK2B 1.0 -1.0 MAP2K1 1.0 -1.0 MAP2K6 1.0 -1.0 MAP3K4 1.0 -1.0 **Inhibition of cell proliferation 1.0 -1.0 PTPN11 1.0 -1.0 **TGF-beta receptor signaling 1.0 -1.0 **No synthesis and signaling 1.0 -1.0 **Inhibition of NO mediated signal transduction 1.0 -1.0 ALOX15 1.0 -1.0 **Inflammation 1.0 -1.0 ARG1 1.0 -1.0 *L-Ornithine 1.0 -1.0 *Urea 1.0 -1.0 CCL17 1.0 -1.0 CCL23 1.0 -1.0 COL1A2 1.0 -1.0 **Fibrosis 1.0 -1.0 *Chitinase 3L3 1.0 -1.0 CCL11 1.0 -1.0 CCL26 1.0 -1.0 HSD3B1 1.0 -1.0 **Steroid Hormone synthesis 1.0 -1.0 IGHE 1.0 -1.0 IGHG4 1.0 -1.0 NOS2 1.0 -1.0 IL1RN 1.0 -1.0 TYK2 1.0 -1.0 *L-Arginine 1.0 -1.0 *L-Citrulline 1.0 -1.0 *NO 1.0 -1.0 *O(,2) 1.0 -1.0 RETNLB 1.0 -1.0 **Myofibroblast differentiation 1.0 -1.0 SERPINB3 1.0 -1.0 SERPINB4 1.0 -1.0 SPRR2B 1.0 -1.0 *Chitinase 3L3 1.0 -1.0 FOXJ1 1.0 -1.0 SCGB3A1 1.0 -1.0 PRKCE 1.0 -1.0 **Smooth muscle contraction 1.0 -1.0 *Tenascin-C 1.0 -1.0 ADCY1 1.0 -1.0 *Cyclic AMP 1.0 -1.0 *Pyrophosphate 1.0 -1.0 **Inhibition of oxygen and reactive oxygen species production 1.0 -1.0 *HCO(,3)('-) 1.0 -1.0 *Putrescine 1.0 -1.0 SPHK1 1.0 -1.0 RAF1 1.0 -1.0 *IGHE 1.0 -1.0 IRS1 1.0 -1.0 IRS2 1.0 -1.0 MAP2K2 1.0 -1.0 PRKCZ 1.0 -1.0 **Intestinal epithelial permeability 1.0 -1.0 **Cell proliferation 1.0 -1.0 MUC5AC 1.0 -1.0 RPS6KA1 1.0 -1.0 **Cell growth 1.0 -1.0 NFKBIA 1.0 -1.0 NFKBIB 1.0 -1.0 **AKT signaling 1.0 -1.0 FES 1.0 -1.0 IGHG1 1.0 -1.0 SOCS5 1.0 -1.0 MTOR B cell:endoplasmic reticulum B cell:endoplasmic reticulum 1.0 -1.0 *Ca('2+) 1.0 -1.0 ITPR1; ITPR2; ITPR3 B cell:mitochondria B cell:mitochondria 1.0 -1.0 BCL2L1 1.0 -1.0 BCL2 B cell:nucleus B cell:nucleus 1.0 -1.0 NFATC2 1.0 -1.0 BCL6 1.0 -1.0 EGR1 1.0 -1.0 ELK1 1.0 -1.0 NFKBIA; NFKBIB; NFKBIE 1.0 -1.0 RELA;REL; NFKB1;RELB; NFKB2 1.0 -1.0 ATF2 1.0 -1.0 STAT3 1.0 -1.0 JUN 1.0 -1.0 IRF1 1.0 -1.0 BRCA1 1.0 -1.0 STAT1; STAT2; IRF9 1.0 -1.0 CEBPB 1.0 -1.0 CREBBP 1.0 -1.0 SMAD7 1.0 -1.0 MYC 1.0 -1.0 MCM5 1.0 -1.0 EP300 1.0 -1.0 STAT5A; STAT5B 1.0 -1.0 STAT6 1.0 -1.0 SOCS1 1.0 -1.0 ODC1 1.0 -1.0 GATA3