Macrophage:extracellular Macrophage:extracellular 1.0 -1.0 IL4 1.0 -1.0 IL2RG;IL4R 1.0 -1.0 TNF 1.0 -1.0 **PTMs(phosphorylation and acetylation) in TNF-alpha-induced NF-kB signaling 1.0 -1.0 ADAM17 1.0 -1.0 **Autophosphorylation Macrophage:membrane Macrophage:membrane 1.0 -1.0 IL2RG;IL4R 1.0 -1.0 TNFRSF1A 1.0 -1.0 **PTMs in BAFF-induced non-canonical NF-kB signaling 1.0 -1.0 KDR 1.0 -1.0 TNFRSF1B Macrophage:cytosol Macrophage:cytosol 1.0 -1.0 **Regulation of Apoptosis by Mithochondrial Proteins 1.0 -1.0 **Anti-Apoptosis 1.0 -1.0 AKT1;AKT2; AKT3 1.0 -1.0 BAD 1.0 -1.0 GSK3B 1.0 -1.0 MAPK1;MAPK3 1.0 -1.0 RPS6KA1 1.0 -1.0 GRB2 1.0 -1.0 SOS1;SOS2 1.0 -1.0 HRAS 1.0 -1.0 RAF1 1.0 -1.0 IRS1 1.0 -1.0 IRS2 1.0 -1.0 JAK1 1.0 -1.0 JAK3 1.0 -1.0 SHC1 1.0 -1.0 PIK3R2;PIK3R1; PIK3R3 1.0 -1.0 MAP2K1 1.0 -1.0 MAP2K2 1.0 -1.0 **Cell growth 1.0 -1.0 **Cell survival 1.0 -1.0 NFKBIA 1.0 -1.0 NFKBIB 1.0 -1.0 PDPK1 1.0 -1.0 PIK3CA;PIK3CB; PIK3CD 1.0 -1.0 *PtdIns(3,4,5)P3 1.0 -1.0 *PtdIns(4,5)P2 1.0 -1.0 SOCS1 1.0 -1.0 **AKT signaling 1.0 -1.0 CHUK;IKBKB 1.0 -1.0 FES 1.0 -1.0 INPP5D 1.0 -1.0 FCER2 1.0 -1.0 CCL11 1.0 -1.0 IGHE 1.0 -1.0 IGHG1 1.0 -1.0 RPS6KB1 1.0 -1.0 **Cell proliferation 1.0 -1.0 SOCS5 1.0 -1.0 IGHG4 1.0 -1.0 MTOR 1.0 -1.0 ERAP1 1.0 -1.0 APAF1 1.0 -1.0 CASP9 1.0 -1.0 BRE 1.0 -1.0 CYCS 1.0 -1.0 HTRA2 1.0 -1.0 DIABLO 1.0 -1.0 CASP10 1.0 -1.0 CASP8 1.0 -1.0 BID 1.0 -1.0 CASP2 1.0 -1.0 CASP7 1.0 -1.0 CASP6 1.0 -1.0 FADD 1.0 -1.0 **Ceramides signaling pathway 1.0 -1.0 CASP8AP2 1.0 -1.0 MAP4K2 1.0 -1.0 MAP3K1 1.0 -1.0 BIRC2 1.0 -1.0 IKBKG 1.0 -1.0 MAPK10;MAPK8; MAPK9 1.0 -1.0 MAP2K4 1.0 -1.0 MAP2K7 1.0 -1.0 XIAP 1.0 -1.0 BIRC3 1.0 -1.0 CRADD 1.0 -1.0 RIPK1 1.0 -1.0 BAG4 1.0 -1.0 TRADD 1.0 -1.0 TRAF2 1.0 -1.0 CFLAR 1.0 -1.0 **PTMs(phosphorylation) in TNF-alpha-induced NF-kB signaling 1.0 -1.0 PRKACA 1.0 -1.0 **PTMs(ubiquitinaition and phosphorilation) in TNF-alpha-induced NF-kB signaling 1.0 -1.0 *1,2-Diacyglycerol 1.0 -1.0 PRKCA 1.0 -1.0 *Phosphatidic acid 1.0 -1.0 *Ca('2+) 1.0 -1.0 DGKA 1.0 -1.0 *IP3 1.0 -1.0 PRKCI 1.0 -1.0 PLCG2 1.0 -1.0 SQSTM1 1.0 -1.0 **PTMs(ubiquitinaition and phosphorylation) in TNF-alpha-induced NF-kB signaling 1.0 -1.0 SRC 1.0 -1.0 MAPK14;MAPK11; MAPK13;MAPK12 1.0 -1.0 **PTMs(phosphorylation and acetylation) in TNF-alpha-induced NF-kB signaling 1.0 -1.0 PRKCD 1.0 -1.0 PRKCE 1.0 -1.0 AZI2 1.0 -1.0 TBK1 1.0 -1.0 ADCY1;ADCY2;ADCY3; ADCY4;ADCY5;ADCY6; ADCY7;ADCY8;ADCY9 1.0 -1.0 *Cyclic AMP 1.0 -1.0 *Pyrophosphate 1.0 -1.0 CDK6 1.0 -1.0 CSNK2A1 1.0 -1.0 PRKAR1A;PRKAR1B; PRKAR2A;PRKAR2B 1.0 -1.0 MAP3K14 1.0 -1.0 PIM1 1.0 -1.0 PIN1 1.0 -1.0 TAB2 1.0 -1.0 TAB1 1.0 -1.0 MAP3K7 1.0 -1.0 *vCyclin (HHV8) 1.0 -1.0 *(2S,3R,4E)-Sphingosine 1-phosphate 1.0 -1.0 **Sphingolipid metabolism 1.0 -1.0 *Sphingosine 1.0 -1.0 CSNK1A1 1.0 -1.0 *Ceramides 1.0 -1.0 BTRC;CUL1; FBXW11;FBXW7; RBX1;SKP1;SKP2 1.0 -1.0 UBB;UBC 1.0 -1.0 UBE2N 1.0 -1.0 MAP3K3 1.0 -1.0 SHARPIN;RNF31; RBCK1 1.0 -1.0 SPHK1 1.0 -1.0 **TNF-alpha-induced Caspase-8 signaling 1.0 -1.0 RELA;NFKB1 1.0 -1.0 UBE2D1 1.0 -1.0 UBE2D3 1.0 -1.0 UBE2V1 1.0 -1.0 **Endothelial cell migration 1.0 -1.0 **Angiogenesis 1.0 -1.0 DAB2IP 1.0 -1.0 MAP3K5 1.0 -1.0 ATF2 1.0 -1.0 **Inflammatory response 1.0 -1.0 **Regulation of apoptosis 1.0 -1.0 **Apoptosis 1.0 -1.0 BMX 1.0 -1.0 NFKB2 1.0 -1.0 **Immune response 1.0 -1.0 SMURF2 1.0 -1.0 TRAF1 1.0 -1.0 TRAF3 1.0 -1.0 ZFP91 Macrophage:endoplasmic reticulum Macrophage:endoplasmic reticulum 1.0 -1.0 *Ca('2+) 1.0 -1.0 ITPR1;ITPR2; ITPR3 Macrophage:mitochondria Macrophage:mitochondria 1.0 -1.0 BCL2 1.0 -1.0 BAX 1.0 -1.0 BMF 1.0 -1.0 BCL2L1 1.0 -1.0 BCL2L11 Macrophage:nucleus Macrophage:nucleus 1.0 -1.0 STAT6 1.0 -1.0 RELA;REL;NFKB1; RELB;NFKB2 1.0 -1.0 ELK1 1.0 -1.0 NFKBIA;NFKBIB; NFKBIE 1.0 -1.0 GATA3 1.0 -1.0 **Caspase cascade 1.0 -1.0 **Cell death 1.0 -1.0 CASP3 1.0 -1.0 JUN 1.0 -1.0 MAP3K14 1.0 -1.0 CREBBP 1.0 -1.0 H3F3A;H3F3B; HIST3H3 1.0 -1.0 EP300 1.0 -1.0 PRKCZ 1.0 -1.0 RPS6KA5 1.0 -1.0 CHUK 1.0 -1.0 PRKCD 1.0 -1.0 **Gene expression