Mast cell:extracellular Mast cell:extracellular 1.0 -1.0 IFNG 1.0 -1.0 IL13 1.0 -1.0 MMP8 1.0 -1.0 IL33 1.0 -1.0 IL4 1.0 -1.0 IL2RG; IL4R 1.0 -1.0 IL9 Mast cell:membrane Mast cell:membrane 1.0 -1.0 FCER1A;FCER1G;MS4A2 1.0 -1.0 GRB2 1.0 -1.0 LAT 1.0 -1.0 IFNGR1;IFNGR2 1.0 -1.0 IL2RG; IL9R;IL4R; IL13RA1 1.0 -1.0 IL13RA2 1.0 -1.0 IL1RL1 1.0 -1.0 IL1RAP Mast cell:cytosol Mast cell:cytosol 1.0 -1.0 **Arachnoid acid production 1.0 -1.0 **Arachnoid acid metabolite production 1.0 -1.0 *1,2-Diacyglycerol 1.0 -1.0 PRKCQ 1.0 -1.0 AKT1; AKT2; AKT3 1.0 -1.0 **AKT signaling 1.0 -1.0 BLNK 1.0 -1.0 PLCG1; PLCG2 1.0 -1.0 SYK 1.0 -1.0 BTK 1.0 -1.0 *Ca('2+) 1.0 -1.0 CALM1; CALM2; CALM3 1.0 -1.0 PPP3CA;PPP3CB;PPP3CC 1.0 -1.0 PLA2G4A; PLA2G4C 1.0 -1.0 LYN 1.0 -1.0 FER 1.0 -1.0 MAP2K3 1.0 -1.0 MAP2K6 1.0 -1.0 GAB2 1.0 -1.0 PIK3R2; PIK3R1; PIK3R3 1.0 -1.0 SOS1; SOS2 1.0 -1.0 LCP2 1.0 -1.0 HRAS 1.0 -1.0 RAF1 1.0 -1.0 IKBKB; CHUK 1.0 -1.0 IKBKG 1.0 -1.0 *IP3 1.0 -1.0 IGHJ3;IGK;IGHE;IGKJ@;IGLJ@; IGKV@;IGHJ6;IGHJ5;IGKC; IGHJ2;IGHJ4;IGLV@;IGHJ1;IGL 1.0 -1.0 MAPK10; MAPK8; MAPK9 1.0 -1.0 MAP2K1; MAP2K2 1.0 -1.0 MAPK14; MAPK11; MAPK13;MAPK12 1.0 -1.0 MAP2K4 1.0 -1.0 MAP3K1 1.0 -1.0 MAP2K7 1.0 -1.0 PAK2 1.0 -1.0 PIK3CB; PIK3CD; PIK3CA 1.0 -1.0 *PtdIns(3,4,5)P3 1.0 -1.0 *PtdIns(4,5)P2 1.0 -1.0 RAC1 1.0 -1.0 VAV1 1.0 -1.0 **ATM/ART regulation of G1/S checkpoint 1.0 -1.0 **Cell cycle regulation 1.0 -1.0 **Regulation of EIF2 activity 1.0 -1.0 **Regulation of translation 1.0 -1.0 **Regulation of EIF4F activity 1.0 -1.0 PRKCA 1.0 -1.0 PRKCD 1.0 -1.0 AFAP1 1.0 -1.0 SRC 1.0 -1.0 RAPGEF1 1.0 -1.0 RAP1A 1.0 -1.0 CAMK2A; CAMK2B;CAMK2D; CAMK2G 1.0 -1.0 CRKL 1.0 -1.0 MAPK1; MAPK3 1.0 -1.0 FANCC 1.0 -1.0 ICAM1 1.0 -1.0 **Cell adhesion 1.0 -1.0 JAK1 1.0 -1.0 JAK2 1.0 -1.0 CBL 1.0 -1.0 SOCS1 1.0 -1.0 EIF2AK2 1.0 -1.0 CDKN1A 1.0 -1.0 PTK2B 1.0 -1.0 MAP3K4 1.0 -1.0 PDPK1 1.0 -1.0 **Inhibition of cell proliferation 1.0 -1.0 PTPN11 1.0 -1.0 **TGF-beta receptor signaling 1.0 -1.0 **No synthesis and signaling 1.0 -1.0 **Inhibition of NO mediated signal transduction 1.0 -1.0 ALOX15 1.0 -1.0 **Inflammation 1.0 -1.0 ARG1 1.0 -1.0 *L-Ornithine 1.0 -1.0 *Urea 1.0 -1.0 CCL17 1.0 -1.0 CCL23 1.0 -1.0 FCER2 1.0 -1.0 COL1A2 1.0 -1.0 **Fibrosis 1.0 -1.0 *Chitinase 3L3 1.0 -1.0 CCL11 1.0 -1.0 CCL26 1.0 -1.0 HSD3B1 1.0 -1.0 **Steroid Hormone synthesis 1.0 -1.0 IGHG4 1.0 -1.0 NOS2 1.0 -1.0 IL1RN 1.0 -1.0 TYK2 1.0 -1.0 *L-Citrulline 1.0 -1.0 *NO 1.0 -1.0 *O(,2) 1.0 -1.0 RETNLB 1.0 -1.0 **Myofibroblast differentiation 1.0 -1.0 SERPINB3 1.0 -1.0 SERPINB4 1.0 -1.0 PTPN6 1.0 -1.0 SPRR2B 1.0 -1.0 CCL2 1.0 -1.0 *Chitinase 3L3 1.0 -1.0 FOXJ1 1.0 -1.0 SCGB3A1 1.0 -1.0 PRKCE 1.0 -1.0 **Smooth muscle contraction 1.0 -1.0 *Tenascin-C 1.0 -1.0 ADCY1 1.0 -1.0 *Cyclic AMP 1.0 -1.0 *Pyrophosphate 1.0 -1.0 **Inhibition of oxygen and reactive oxygen species production 1.0 -1.0 *HCO(,3)('-) 1.0 -1.0 *Putrescine 1.0 -1.0 SPHK1 1.0 -1.0 GRB2 1.0 -1.0 IGHE 1.0 -1.0 IRS1 1.0 -1.0 IRS2 1.0 -1.0 PRKCZ 1.0 -1.0 **Intestinal epithelial permeability 1.0 -1.0 **Cell proliferation 1.0 -1.0 MUC5AC 1.0 -1.0 **GM-CSF signalling 1.0 -1.0 **Inflammatory response 1.0 -1.0 **IL-13 signaling via JAK-STAT 1.0 -1.0 **IL-13 signaling via PI3K-ERK 1.0 -1.0 **IL-5 signalling 1.0 -1.0 **IL-6 signalling pathway 1.0 -1.0 **IL-8 dependent cell migration and adhesion 1.0 -1.0 **Inhibitory action of Lipoxins on pro-inflammatory TNF-alpha signalling 1.0 -1.0 NOS3 1.0 -1.0 SELE 1.0 -1.0 RPS6KA5 1.0 -1.0 CSF2 1.0 -1.0 CXCL1 1.0 -1.0 H2AFX;H2AFZ;HIST1H2AC;HIST1H2AD; HIST1H2AG;HIST1H2AI;HIST1H2AJ; HIST1H2AK;HIST1H2AL;HIST1H2AM;HIST2H2AC 1.0 -1.0 H2BFS;HIST1H2BB;HIST1H2BC;HIST1H2BD; HIST1H2BE;HIST1H2BF;HIST1H2BG;HIST1H2BH; HIST1H2BI;HIST1H2BJ;HIST1H2BL;HIST1H2BM; HIST1H2BN;HIST1H2BO;HIST2H2BE;LOC102724334 1.0 -1.0 IL13 1.0 -1.0 IL17F 1.0 -1.0 IL5 1.0 -1.0 IL6 1.0 -1.0 CXCL8 1.0 -1.0 MYD88 1.0 -1.0 IRAK1 1.0 -1.0 TRAF6 1.0 -1.0 IRAK4 1.0 -1.0 *N-omega-Hydroxy-L-arginine 1.0 -1.0 TNF 1.0 -1.0 VCAM1 1.0 -1.0 MAP3K14 1.0 -1.0 **Angiogenesis 1.0 -1.0 TMED1 1.0 -1.0 TAB1 1.0 -1.0 MAP3K7 1.0 -1.0 TAB2 1.0 -1.0 UBB;UBC 1.0 -1.0 **Regulation of Apoptosis by Mithochondrial Proteins 1.0 -1.0 **Anti-Apoptosis 1.0 -1.0 BAD 1.0 -1.0 GSK3B 1.0 -1.0 RPS6KA1 1.0 -1.0 JAK3 1.0 -1.0 SHC1 1.0 -1.0 **Cell growth 1.0 -1.0 **Cell survival 1.0 -1.0 NFKBIA 1.0 -1.0 NFKBIB 1.0 -1.0 FES 1.0 -1.0 INPP5D 1.0 -1.0 IGHG1 1.0 -1.0 RPS6KB1 1.0 -1.0 SOCS5 1.0 -1.0 MTOR 1.0 -1.0 RELA;NFKB1 1.0 -1.0 **IL22 signaling pathway Mast cell:endoplasmic reticulum Mast cell:endoplasmic reticulum 1.0 -1.0 *Ca('2+) 1.0 -1.0 ITPR1; ITPR2; ITPR3 Mast cell:mitochondria Mast cell:mitochondria 1.0 -1.0 BCL2 Mast cell:nucleus Mast cell:nucleus 1.0 -1.0 NFATC4 1.0 -1.0 MAPK1; MAPK3 1.0 -1.0 ELK1 1.0 -1.0 NFKBIA; NFKBIB; NFKBIE 1.0 -1.0 RELA;REL; NFKB1;RELB; NFKB2 1.0 -1.0 JUN 1.0 -1.0 ATF2 1.0 -1.0 BRCA1 1.0 -1.0 STAT1; STAT2; IRF9 1.0 -1.0 CEBPB 1.0 -1.0 CREBBP 1.0 -1.0 IRF1 1.0 -1.0 SMAD7 1.0 -1.0 MYC 1.0 -1.0 MCM5 1.0 -1.0 EP300 1.0 -1.0 STAT3 1.0 -1.0 STAT5A; STAT5B 1.0 -1.0 STAT6 1.0 -1.0 SOCS1 1.0 -1.0 ODC1 1.0 -1.0 GATA3 1.0 -1.0 BCL3 1.0 -1.0 IL22 1.0 -1.0 SOCS3 1.0 -1.0 CISH 1.0 -1.0 SOCS2 1.0 -1.0 *L-Arginine