Fibroblast:extracellular Fibroblast:extracellular 1.0 -1.0 IL13 1.0 -1.0 MMP8 1.0 -1.0 **ECM remodiling 1.0 -1.0 **Bone destruction 1.0 -1.0 **Osteoclast differentiation 1.0 -1.0 **Th17 cell differentiation 1.0 -1.0 IL17A 1.0 -1.0 IL6 1.0 -1.0 IL1B 1.0 -1.0 IL17F 1.0 -1.0 MMP1 1.0 -1.0 MMP9 1.0 -1.0 TNFSF11 1.0 -1.0 MMP3 1.0 -1.0 IL21 1.0 -1.0 IL12B;IL23A 1.0 -1.0 **Fibrosis 1.0 -1.0 **Inflammation in asthma 1.0 -1.0 **Cell-matrix glycoconjugates 1.0 -1.0 **Extracellular matrix synthesis and remodeling 1.0 -1.0 **Fibroblast/myofibroblast cell proliferation 1.0 -1.0 **Hyperplasia 1.0 -1.0 **Fibroblast/myofibroblast proliferation in asthmatic airways 1.0 -1.0 TGFB1 1.0 -1.0 **TGF-beta 1-mediated induction of EMT in normal and asthmatic airway epithelium 1.0 -1.0 **Th2 cytokine and TNF-alpha-induced profibrotic response in asthmatic airway fibroblast/myofibroblast 1.0 -1.0 BGN 1.0 -1.0 **Cell migration 1.0 -1.0 DCN 1.0 -1.0 **Hypertrophy of asthmatic airway smooth muscle cells 1.0 -1.0 **Disruption of epithelial layer restitution in asthma 1.0 -1.0 SERPINE1 1.0 -1.0 **MAPK-mediated proliferation of normal and asthmatic smooth muscle cells 1.0 -1.0 TNC 1.0 -1.0 THBS2 1.0 -1.0 TGFB2 1.0 -1.0 TGFB3 1.0 -1.0 **Eosinophil accumulation i n asthma 1.0 -1.0 **Excessive mucus production in asthma 1.0 -1.0 **Interleukins-induced inflammatory signaling in normal and asthmatic airway epithelium 1.0 -1.0 **Th1/Th2 cell imbalance in favor of Th2 cells 1.0 -1.0 **Mast cell accumulation in asthma 1.0 -1.0 **Prostaglanding 2 biosynthesis and metabolism 1.0 -1.0 IL11 1.0 -1.0 EDN1 1.0 -1.0 IFNG 1.0 -1.0 IL33 1.0 -1.0 NGF 1.0 -1.0 TNF 1.0 -1.0 IL4 Fibroblast:membrane Fibroblast:membrane 1.0 -1.0 IL4R;IL13RA1 1.0 -1.0 IL13RA2 1.0 -1.0 IL17RA 1.0 -1.0 IL17RC 1.0 -1.0 LTB4R 1.0 -1.0 LTB4R2 1.0 -1.0 **Cell adhesion 1.0 -1.0 ABCC5 1.0 -1.0 ITGA1 1.0 -1.0 ITGA2 1.0 -1.0 ITGA3 1.0 -1.0 ITGA5 1.0 -1.0 ITGB1 1.0 -1.0 TGFBR1 1.0 -1.0 TGFBR2 1.0 -1.0 ADAM33 1.0 -1.0 KITLG 1.0 -1.0 EDNRA 1.0 -1.0 ICAM1 1.0 -1.0 IL1R1 1.0 -1.0 TNFRSF1A 1.0 -1.0 GRB2 Fibroblast:cytosol Fibroblast:cytosol 1.0 -1.0 **No synthesis and signaling 1.0 -1.0 **Inhibition of NO mediated signal transduction 1.0 -1.0 ALOX15 1.0 -1.0 **Inflammation 1.0 -1.0 ARG1 1.0 -1.0 *L-Ornithine 1.0 -1.0 *Urea 1.0 -1.0 CCL17 1.0 -1.0 CCL23 1.0 -1.0 FCER2 1.0 -1.0 **Fibrosis 1.0 -1.0 *Chitinase 3L3 1.0 -1.0 CCL11 1.0 -1.0 CCL26 1.0 -1.0 HSD3B1 1.0 -1.0 **Steroid Hormone synthesis 1.0 -1.0 IGHE 1.0 -1.0 IGHG4 1.0 -1.0 NOS2 1.0 -1.0 IL1RN 1.0 -1.0 JAK1 1.0 -1.0 JAK2 1.0 -1.0 TYK2 1.0 -1.0 *L-Arginine 1.0 -1.0 *L-Citrulline 1.0 -1.0 *NO 1.0 -1.0 *O(,2) 1.0 -1.0 RETNLB 1.0 -1.0 **Myofibroblast differentiation 1.0 -1.0 SERPINB3 1.0 -1.0 SERPINB4 1.0 -1.0 PTPN6 1.0 -1.0 SPRR2B 1.0 -1.0 CCL2 1.0 -1.0 *Chitinase 3L3 1.0 -1.0 FOXJ1 1.0 -1.0 SCGB3A1 1.0 -1.0 *1,2-Diacyglycerol 1.0 -1.0 PRKCA;PRKCG;PRKD1;PRKCI; PRKD3;PRKD2;PRKCD;PRKCE; PRKCZ;PRKCH;PRKCB;PRKCQ 1.0 -1.0 AKT1;AKT2; AKT3 1.0 -1.0 **Smooth muscle contraction 1.0 -1.0 *Tenascin-C 1.0 -1.0 ADCY9;ADCY5;ADCY2; ADCY7;ADCY3;ADCY1; ADCY4;ADCY6;ADCY8 1.0 -1.0 *Cyclic AMP 1.0 -1.0 *Pyrophosphate 1.0 -1.0 *Ca('2+) 1.0 -1.0 CALM1;CALM2; CALM3 1.0 -1.0 **Inhibition of oxygen and reactive oxygen species production 1.0 -1.0 *HCO(,3)('-) 1.0 -1.0 *Putrescine 1.0 -1.0 MAPK1; MAPK3 1.0 -1.0 SPHK1 1.0 -1.0 GRB2 1.0 -1.0 SOS1;SOS2 1.0 -1.0 HRAS 1.0 -1.0 RAF1 1.0 -1.0 IGHE 1.0 -1.0 PTPN11 1.0 -1.0 *IP3 1.0 -1.0 IRS1 1.0 -1.0 PIK3R2;PIK3R1; PIK3R3 1.0 -1.0 IRS2 1.0 -1.0 PLCG1 1.0 -1.0 MAP2K1; MAP2K2 1.0 -1.0 PIK3CB;PIK3CD; PIK3CA 1.0 -1.0 *PtdIns(3,4,5)P3 1.0 -1.0 **Intestinal epithelial permeability 1.0 -1.0 *PtdIns(4,5)P2 1.0 -1.0 **Cell proliferation 1.0 -1.0 MUC5AC 1.0 -1.0 **Chemokines and adhesion 1.0 -1.0 **Chemotaxis 1.0 -1.0 **GM-CSF signaling 1.0 -1.0 **Granulopoiesis 1.0 -1.0 **IL-6 signaling pathway 1.0 -1.0 **Inflammatory response 1.0 -1.0 **PGE2 synthesis 1.0 -1.0 **Prostaglandin 2 biosynthesis 1.0 -1.0 **Transcription regulation of granulocyte development 1.0 -1.0 GSK3B 1.0 -1.0 DEFB4A; DEFB4B 1.0 -1.0 **Antibacterial activity 1.0 -1.0 **Chemotaxis of CCR6-positive T cells 1.0 -1.0 **Chemotaxis of CCR6-positive dendritic cells 1.0 -1.0 CCL7 1.0 -1.0 LCN2 1.0 -1.0 PTGS2 1.0 -1.0 CCL20 1.0 -1.0 TRAF3IP2 1.0 -1.0 IKBKG 1.0 -1.0 MAP3K7 1.0 -1.0 TRAF6 1.0 -1.0 CXCL5 1.0 -1.0 **Neutrophil chemotaxis 1.0 -1.0 CHUK;IKBKB 1.0 -1.0 FOS;ATF2;FOSB;JUN; FOSL1;JUND;FOSL2;JUNB 1.0 -1.0 CSF3 1.0 -1.0 CXCL6 1.0 -1.0 CSF2 1.0 -1.0 CXCL1 1.0 -1.0 ICAM1 1.0 -1.0 **Cell adhesion 1.0 -1.0 MUC5B 1.0 -1.0 CXCL8 1.0 -1.0 MAP2K3 1.0 -1.0 MAPK14;MAPK11; MAPK13;MAPK12 1.0 -1.0 MAP2K6 1.0 -1.0 MAP3K14 1.0 -1.0 TNFSF11 1.0 -1.0 **MAPK activation 1.0 -1.0 MAPK10;MAPK8; MAPK9 1.0 -1.0 **PTMs in IL-17-inducced CIKS-independent singaling pathway 1.0 -1.0 **PTMs in IL-17-induced CIKS-independent singaling pathway 1.0 -1.0 TNIP2 1.0 -1.0 MAP3K8 1.0 -1.0 **Regulation of gene expression 1.0 -1.0 TRAF2 1.0 -1.0 TRAF5 1.0 -1.0 UBB;UBC 1.0 -1.0 UBE2N 1.0 -1.0 **PTMs in IL-17-induced CIKS-dependent NF-kB signaling and mRNA stabilization 1.0 -1.0 RELA;REL;NFKB1; RELB;NFKB2 1.0 -1.0 IKBKE 1.0 -1.0 **PTMs in IL-17-induced CIKS-independent signaling pathway 1.0 -1.0 MAP3K3 1.0 -1.0 MAP2K4 1.0 -1.0 TAB1 1.0 -1.0 TAB2 1.0 -1.0 UBA1 1.0 -1.0 UBE2V1 1.0 -1.0 **mRNA stabilization 1.0 -1.0 TRAF4 1.0 -1.0 BTRC;CUL1; FBXW11;FBXW7; RBX1;SKP1;SKP2 1.0 -1.0 TRAF3 1.0 -1.0 SRSF1 1.0 -1.0 TBK1 1.0 -1.0 USP25 1.0 -1.0 **PTMs in IL-17-induced CIKS-dependent MAPK signaling pathways 1.0 -1.0 DUSP1 1.0 -1.0 MIR101-2; MIR101-1 1.0 -1.0 RPS6KA1; RPS6KA2; RPS6KA3 1.0 -1.0 JAK3 1.0 -1.0 STAT2 1.0 -1.0 PDPK1 1.0 -1.0 MAPKAPK2 1.0 -1.0 **AKT signaling 1.0 -1.0 **Proliferation and survival of cancer cells 1.0 -1.0 **Expression of proinflammatory cytokines 1.0 -1.0 **Fc gamma R-mediated phagocytosis in macrophages 1.0 -1.0 PIK3ACA 1.0 -1.0 RAC1 1.0 -1.0 SYK 1.0 -1.0 **G-protein-mediated ERK signaling 1.0 -1.0 **Mast cell chemotaxis 1.0 -1.0 **Production and main functions of biologically active prostaglandins and Thromboxane A2 1.0 -1.0 **Transepithelial migration of neutrophils 1.0 -1.0 **ROS production 1.0 -1.0 **Bacterial activity 1.0 -1.0 HNRNPD 1.0 -1.0 CAMK2A;CAMK2B; CAMK2D;CAMK2G 1.0 -1.0 NOS3 1.0 -1.0 NOS1 1.0 -1.0 RAPGEF3 1.0 -1.0 GNA15 1.0 -1.0 PLCB3;PLCB4; PLCB2;PLCB1 1.0 -1.0 GNAI1;GNAI2; GNAI3;GNAO1; GNAZ 1.0 -1.0 GNB1;GNB2;GNB3;GNB4; GNB5;GNG10;GNG11; GNG12;GNG13;GNG2; GNG3;GNG4;GNG5;GNG7; GNG8;GNGT1;GNGT2 1.0 -1.0 GNA11; GNAQ 1.0 -1.0 PIK3CG 1.0 -1.0 PIK3R5 1.0 -1.0 *NADPH oxidase 1.0 -1.0 **Phagocytosis 1.0 -1.0 NCF1 1.0 -1.0 RAP1A 1.0 -1.0 **IL-1 beta- and Endothelin-1-induced fibroblast/myofibroblast migration and extracellular matrix production in asthmatic airways 1.0 -1.0 **JNK pathway 1.0 -1.0 **TGF-beta receptor signaling 1.0 -1.0 *1,2-diacyl-glycerol 3-phosphocholine 1.0 -1.0 *Choline phosphate 1.0 -1.0 COL1A1; COL1A2 1.0 -1.0 EDN1 1.0 -1.0 MMP1 1.0 -1.0 MMP13 1.0 -1.0 MMP2 1.0 -1.0 MMP9 1.0 -1.0 MMP3 1.0 -1.0 KIAA1731NL; TIMP2 1.0 -1.0 COL4A1 1.0 -1.0 COL5A1 1.0 -1.0 FN1 1.0 -1.0 HAS1 1.0 -1.0 *Hyaluronic acid 1.0 -1.0 HAS2 1.0 -1.0 *Phosphatidylcholine-specific phospholipase C 1.0 -1.0 COL3A1 1.0 -1.0 TIMP1 1.0 -1.0 TIMP3 1.0 -1.0 *PC-PLC 1.0 -1.0 **Interleukins-induced inflammatory response in asthmatic airway fibroblast 1.0 -1.0 **TNFR1 signaling pathway ATP]]> ATP]]> 1.0 -1.0 *ATP ADP]]> ADP]]> 1.0 -1.0 *ADP PO(,4)('3-)]]> PO(,4)('3-)]]> 1.0 -1.0 *PO(,4)('3-) 1.0 -1.0 ACTA2 1.0 -1.0 BDKRB1 1.0 -1.0 *UDP 1.0 -1.0 IL1B 1.0 -1.0 PDGFRA 1.0 -1.0 PTGS1 1.0 -1.0 IL2RG;IL4R; IL13RA1 1.0 -1.0 PDGFA 1.0 -1.0 IL13RA2 1.0 -1.0 NGF 1.0 -1.0 NTRK1 1.0 -1.0 NSMAF 1.0 -1.0 BGN 1.0 -1.0 *UDP-D-glucuronic acid 1.0 -1.0 *UDP-N-acetyl-D-glucosamine 1.0 -1.0 KNG1 Fibroblast:endoplasmic reticulum Fibroblast:endoplasmic reticulum 1.0 -1.0 *Ca('2+) 1.0 -1.0 ITPR1;ITPR2; ITPR3 Fibroblast:nucleus Fibroblast:nucleus 1.0 -1.0 STAT1 1.0 -1.0 STAT3 1.0 -1.0 STAT5A; STAT5B 1.0 -1.0 STAT6 1.0 -1.0 SOCS1 1.0 -1.0 ODC1 1.0 -1.0 ELK1 1.0 -1.0 MYC 1.0 -1.0 CEBPB 1.0 -1.0 CEBPD 1.0 -1.0 SP1 1.0 -1.0 NFKBIA;NFKBIB; NFKBIE 1.0 -1.0 RELA;REL;NFKB1; RELB;NFKB2 1.0 -1.0 **Regulation of gene expression 1.0 -1.0 **Inhibition of gene expression 1.0 -1.0 FOS;ATF2;FOSB;J UN;FOSL1;JUND; FOSL2;JUNB 1.0 -1.0 STAT4 1.0 -1.0 MAPK1; MAPK3 1.0 -1.0 SMAD3 1.0 -1.0 SMAD2 1.0 -1.0 SMAD4 1.0 -1.0 ETS1 1.0 -1.0 MAPK11;MAPK12; MAPK13;MAPK14 Hyaluronic acid]]> Hyaluronic acid]]> 1.0 -1.0 *Hyaluronic acid 1.0 -1.0 *Leukotriene B4