Airway smooth muscle cell:extracellular Airway smooth muscle cell:extracellular 2.0 -1.0 **Smooth muscle contraction 1.0 -1.0 **GPCRs in the regulation of smooth muscle tone 1.0 -1.0 *Histamine 1.0 -1.0 IFNB1 1.0 -1.0 IFNG 1.0 -1.0 IL13 1.0 -1.0 IL4 1.0 -1.0 TNF 1.0 -1.0 *Prostaglandin E2 1.0 -1.0 **Mast cell chemotaxis 1.0 -1.0 TGFB2; TGFB1; TGFB3 1.0 -1.0 AGT 1.0 -1.0 CSF2 1.0 -1.0 LTBP1 1.0 -1.0 ELANE 1.0 -1.0 SERPINE1 1.0 -1.0 PLAU 1.0 -1.0 PLG 1.0 -1.0 TPSAB1; TPSB2;TPSD1; TPSG1 Airway smooth muscle cell:membrane Airway smooth muscle cell:membrane 1.0 -1.0 HRH1 1.0 -1.0 IFNAR1; IFNAR2 1.0 -1.0 IFNGR1; IFNGR2 1.0 -1.0 IL2RG;IL4R; IL13RA1 1.0 -1.0 ABCC4 1.0 -1.0 PTGER2 1.0 -1.0 PTGER3 1.0 -1.0 PTGER4 1.0 -1.0 SLCO2A1 1.0 -1.0 AGTR1 1.0 -1.0 TGFBR1 1.0 -1.0 TGFBR2 1.0 -1.0 TGFBR3 1.0 -1.0 TLR4 1.0 -1.0 F2RL1 Airway smooth muscle cell:cytosol Airway smooth muscle cell:cytosol 1.0 -1.0 **GM-CSF signaling 1.0 -1.0 **Inflammatory response 2.0 -1.0 **GPCRs in the regulation of smooth muscle tone 1.0 -1.0 **IL-6 signaling 1.0 -1.0 **Inhibitory action of Lipoxins on pro-inflammatory TNF-alpha signaling 1.0 -1.0 **Inhibitory action of lipoxins on IL-8 and Leukotriene B4-induced neutrophil migration 1.0 -1.0 **Leukocyte chemotaxis 1.0 -1.0 **Cell adhesion 1.0 -1.0 *1,2-Diacyglycerol 1.0 -1.0 PRKCA 1.0 -1.0 *Ca('2+) 1.0 -1.0 PPP3CA; PPP3CB; PPP3CC 1.0 -1.0 PPP3R1; PPP3R2 1.0 -1.0 CALM1; CALM2; CALM3 1.0 -1.0 PLA2G4A; PLA2G4C 1.0 -1.0 NOS3 1.0 -1.0 NOS2 1.0 -1.0 MAPK3 1.0 -1.0 MAPK1 1.0 -1.0 GNA11; GNAQ 1.0 -1.0 GNG10;GNG13;GNG4;GNG2; GNGT1;GNG12;GNB3;GNG3; GNG5;GNB1;GNGT2;GNB5;GNB2; GNG7;GNB4;GNG11;GNG8 1.0 -1.0 PLCB1;PLCB2; PLCB3;PLCB4 1.0 -1.0 CSF2 1.0 -1.0 MAPK10; MAPK8; MAPK9 1.0 -1.0 MAPK11; MAPK12; MAPK13;MAPK14 1.0 -1.0 NFKBIB; NFKBIE; NFKBIA 1.0 -1.0 ICAM1 1.0 -1.0 CHUK 1.0 -1.0 IKBKB 1.0 -1.0 IL6 1.0 -1.0 CXCL8 1.0 -1.0 *IP3 1.0 -1.0 MAP2K1 1.0 -1.0 MAP2K2 1.0 -1.0 MMP9 1.0 -1.0 TNF 1.0 -1.0 VCAM1 1.0 -1.0 RAF1 1.0 -1.0 *PtdIns(4,5)P2 1.0 -1.0 F3 1.0 -1.0 **Blood coagulation 1.0 -1.0 MMP1 1.0 -1.0 MMP13 1.0 -1.0 MMP3 1.0 -1.0 **Prostaglandin synthesis 1.0 -1.0 **Nitric Oxide synthesis 1.0 -1.0 **Contraction 1.0 -1.0 **Hypersensitivity 1.0 -1.0 **IL-13 signaling via JAK-STAT 1.0 -1.0 **RhoA-dependent regulation of normal and asthmatic smooth muscle contraction 1.0 -1.0 CD38 1.0 -1.0 **Calcium-dependent regulation of normal and asthmatic smooth muscle contraction 1.0 -1.0 JAK1 1.0 -1.0 TYK2 1.0 -1.0 IRS1 1.0 -1.0 PIK3R1; PIK3R2 1.0 -1.0 IRS2 1.0 -1.0 STAT2 1.0 -1.0 PIK3CD 1.0 -1.0 **TNF-alpha and IL-1 beta-mediated regulation of contraction and secretion of inflammatory factors in normal and asthmatic smooth muscle 1.0 -1.0 PRKCE 1.0 -1.0 *Prostaglandin E2 1.0 -1.0 AKT1;AKT2;AKT3 1.0 -1.0 ADCY1;ADCY2;ADCY3;ADCY4; ADCY5;ADCY6;ADCY7; ADCY8;ADCY9 1.0 -1.0 *Cyclic AMP 1.0 -1.0 *Pyrophosphate 1.0 -1.0 *Arachidonic acid 1.0 -1.0 *Prostaglandin G2 1.0 -1.0 PTGS1 1.0 -1.0 *Electron acceptor 1.0 -1.0 *Prostaglandin H2 1.0 -1.0 PTGS2 1.0 -1.0 PTGES 1.0 -1.0 **Calcium signaling 1.0 -1.0 PRKAR1A;PRKAR1B; PRKAR2A;PRKAR2B 1.0 -1.0 **Cell proliferation 1.0 -1.0 *Electron donor 1.0 -1.0 GNAI1;GNAI2; GNAO1;GNAI3; GNAZ 1.0 -1.0 GNAS 1.0 -1.0 PIK3CB 1.0 -1.0 PIK3CG 1.0 -1.0 *O(,2) 1.0 -1.0 *Prostaglandin E2 1.0 -1.0 *PtdIns(3,4,5)P3 1.0 -1.0 PRKACA; PRKACB; PRKACG 1.0 -1.0 **Angiotensin activation of ERK 1.0 -1.0 **Angiotensin signaling via PYK2 1.0 -1.0 **G-Proteins mediated regulation MAPK-ERK signaling 1.0 -1.0 **TLR2 and TLR4 singaling pathways 1.0 -1.0 EGR1 1.0 -1.0 IRAK1 1.0 -1.0 MYD88 1.0 -1.0 ROCK1; ROCK2 1.0 -1.0 RHOA 1.0 -1.0 **Extracellular matrix-regulated proliferation of airway smooth muscle cells in asthma 1.0 -1.0 **Hypertrophy of asthmatic airway smooth muscle cells 1.0 -1.0 **MAPK-independent proliferation of normal and asthmatic smooth muscle cells 1.0 -1.0 **MAPK-mediated proliferation of normal and asthmatic smooth muscle cells Airway smooth muscle cell:endoplasmic reticulum Airway smooth muscle cell:endoplasmic reticulum 1.0 -1.0 *Ca('2+) 1.0 -1.0 ITPR1;ITPR2; ITPR3 1.0 -1.0 ATP2A2 Airway smooth muscle cell:nucleus Airway smooth muscle cell:nucleus 1.0 -1.0 NFATC1 1.0 -1.0 FOS;ATF2;FOSB; JUN;FOSL1;JUND; FOSL2;JUNB 1.0 -1.0 NFKB1;RELA 1.0 -1.0 MIR133A1; MIR133A2 1.0 -1.0 IRF1 1.0 -1.0 STAT1 1.0 -1.0 STAT6 1.0 -1.0 RHOA 1.0 -1.0 MAPK1;MAPK3 1.0 -1.0 CREB1 1.0 -1.0 MAP2K1; MAP2K2 1.0 -1.0 NFKBIA