Goblet cell:extracellular Goblet cell:extracellular 1.0 -1.0 *Histamine 1.0 -1.0 IL13 1.0 -1.0 MMP8 1.0 -1.0 **ECM remodiling 1.0 -1.0 **Bone destruction 1.0 -1.0 **Osteoclast differentiation 1.0 -1.0 **Th17 cell differentiation 1.0 -1.0 IL17A 1.0 -1.0 IL6 1.0 -1.0 IL1B 1.0 -1.0 IL17F 1.0 -1.0 MMP1 1.0 -1.0 MMP9 1.0 -1.0 TNFSF11 1.0 -1.0 MMP3 1.0 -1.0 IL21 1.0 -1.0 IL12B;IL23A Goblet cell:membrane Goblet cell:membrane 1.0 -1.0 HRH2 1.0 -1.0 IL4R; IL13RA1 1.0 -1.0 IL13RA2 1.0 -1.0 IL17RA 1.0 -1.0 IL17RC Goblet cell:cytosol Goblet cell:cytosol 1.0 -1.0 ADCY9;ADCY5;ADCY2; ADCY7;ADCY3;ADCY1; ADCY4;ADCY6;ADCY8 1.0 -1.0 *Cyclic AMP 1.0 -1.0 *Pyrophosphate 1.0 -1.0 IL10 1.0 -1.0 TNF 1.0 -1.0 PRKAR1A;PRKAR1B; PRKAR2A;PRKAR2B 1.0 -1.0 MAPK1;MAPK3 1.0 -1.0 GNAS 1.0 -1.0 **Anti-inflammatory response 1.0 -1.0 IL12B 1.0 -1.0 MAP2K1; MAP2K2 1.0 -1.0 PRKACA;PRKACB; PRKACG 1.0 -1.0 RAF1 1.0 -1.0 **No synthesis and signaling 1.0 -1.0 **Inhibition of NO mediated signal transduction 1.0 -1.0 ALOX15 1.0 -1.0 **Inflammation 1.0 -1.0 ARG1 1.0 -1.0 *L-Ornithine 1.0 -1.0 *Urea 1.0 -1.0 CCL17 1.0 -1.0 CCL23 1.0 -1.0 FCER2 1.0 -1.0 COL1A2 1.0 -1.0 **Fibrosis 1.0 -1.0 *Chitinase 3L3 1.0 -1.0 CCL11 1.0 -1.0 CCL26 1.0 -1.0 HSD3B1 1.0 -1.0 **Steroid Hormone synthesis 1.0 -1.0 IGHE 1.0 -1.0 IGHG4 1.0 -1.0 NOS2 1.0 -1.0 IL1RN 1.0 -1.0 JAK1 1.0 -1.0 JAK2 1.0 -1.0 TYK2 1.0 -1.0 *L-Arginine 1.0 -1.0 *L-Citrulline 1.0 -1.0 *NO 1.0 -1.0 *O(,2) 1.0 -1.0 PRKCD 1.0 -1.0 RETNLB 1.0 -1.0 **Myofibroblast differentiation 1.0 -1.0 SERPINB3 1.0 -1.0 SERPINB4 1.0 -1.0 PTPN6 1.0 -1.0 SPRR2B 1.0 -1.0 CCL2 1.0 -1.0 *Chitinase 3L3 1.0 -1.0 FOXJ1 1.0 -1.0 SCGB3A1 1.0 -1.0 *1,2-Diacyglycerol 1.0 -1.0 PRKCE 1.0 -1.0 AKT1;AKT2; AKT3 1.0 -1.0 **Smooth muscle contraction 1.0 -1.0 *Tenascin-C 1.0 -1.0 *Ca('2+) 1.0 -1.0 CALM1; CALM2; CALM3 1.0 -1.0 **Inhibition of oxygen and reactive oxygen species production 1.0 -1.0 *HCO(,3)('-) 1.0 -1.0 *Putrescine 1.0 -1.0 SPHK1 1.0 -1.0 GRB2 1.0 -1.0 SOS1;SOS2 1.0 -1.0 HRAS 1.0 -1.0 IGHE 1.0 -1.0 PTPN11 1.0 -1.0 *IP3 1.0 -1.0 IRS1 1.0 -1.0 PIK3R2; PIK3R1; PIK3R3 1.0 -1.0 IRS2 1.0 -1.0 PLCG1 1.0 -1.0 PIK3CB; PIK3CD; PIK3CA 1.0 -1.0 *PtdIns(3,4,5)P3 1.0 -1.0 PRKCZ 1.0 -1.0 **Intestinal epithelial permeability 1.0 -1.0 *PtdIns(4,5)P2 1.0 -1.0 **Cell proliferation 1.0 -1.0 MUC5AC 1.0 -1.0 **Chemokines and adhesion 1.0 -1.0 **Chemotaxis 1.0 -1.0 **GM-CSF signaling 1.0 -1.0 **Granulopoiesis 1.0 -1.0 **IL-6 signaling pathway 1.0 -1.0 **Inflammatory response 1.0 -1.0 **PGE2 synthesis 1.0 -1.0 **Prostaglandin 2 biosynthesis 1.0 -1.0 **Transcription regulation of granulocyte development 1.0 -1.0 GSK3B 1.0 -1.0 DEFB4A; DEFB4B 1.0 -1.0 **Antibacterial activity 1.0 -1.0 **Chemotaxis of CCR6-positive T cells 1.0 -1.0 **Chemotaxis of CCR6-positive dendritic cells 1.0 -1.0 CCL7 1.0 -1.0 LCN2 1.0 -1.0 PTGS2 1.0 -1.0 CCL20 1.0 -1.0 TRAF3IP2 1.0 -1.0 IKBKG 1.0 -1.0 MAP3K7 1.0 -1.0 TRAF6 1.0 -1.0 CXCL5 1.0 -1.0 **Neutrophil chemotaxis 1.0 -1.0 CHUK;IKBKB 1.0 -1.0 JUN;FOS 1.0 -1.0 CSF3 1.0 -1.0 CXCL6 1.0 -1.0 CSF2 1.0 -1.0 CXCL1 1.0 -1.0 ICAM1 1.0 -1.0 **Cell adhesion 1.0 -1.0 MUC5B 1.0 -1.0 CXCL8 1.0 -1.0 MAP2K3 1.0 -1.0 MAPK14;MAPK11; MAPK13;MAPK12 1.0 -1.0 MAP2K6 1.0 -1.0 MAP3K14 1.0 -1.0 TNFSF11 1.0 -1.0 **MAPK activation 1.0 -1.0 MAPK10;MAPK8; MAPK9 1.0 -1.0 **PTMs in IL-17-inducced CIKS-independent singaling pathway 1.0 -1.0 **PTMs in IL-17-induced CIKS-independent singaling pathway 1.0 -1.0 TNIP2 1.0 -1.0 MAP3K8 1.0 -1.0 **Regulation of gene expression 1.0 -1.0 TRAF2 1.0 -1.0 TRAF5 1.0 -1.0 UBB;UBC 1.0 -1.0 UBE2N 1.0 -1.0 **PTMs in IL-17-induced CIKS-dependent NF-kB signaling and mRNA stabilization 1.0 -1.0 RELA;REL;NFKB1; RELB;NFKB2 1.0 -1.0 IKBKE 1.0 -1.0 **PTMs in IL-17-induced CIKS-independent signaling pathway 1.0 -1.0 MAP3K3 1.0 -1.0 MAP2K4 1.0 -1.0 TAB1 1.0 -1.0 TAB2 1.0 -1.0 UBA1 1.0 -1.0 UBE2V1 1.0 -1.0 **mRNA stabilization 1.0 -1.0 TRAF4 1.0 -1.0 BTRC;CUL1;FBXW11; FBXW7;RBX1;SKP1;SKP2 1.0 -1.0 TRAF3 1.0 -1.0 SRSF1 1.0 -1.0 TBK1 1.0 -1.0 USP25 1.0 -1.0 **PTMs in IL-17-induced CIKS-dependent MAPK signaling pathways 1.0 -1.0 DUSP1 1.0 -1.0 MIR101-2; MIR101-1 1.0 -1.0 RPS6KA1;RPS6KA2; RPS6KA3 1.0 -1.0 JAK3 1.0 -1.0 STAT2 1.0 -1.0 PDPK1 1.0 -1.0 MAPKAPK2 Goblet cell:endoplasmic reticulum Goblet cell:endoplasmic reticulum 1.0 -1.0 *Ca('2+) 1.0 -1.0 ITPR1;ITPR2; ITPR3 Goblet cell:nucleus Goblet cell:nucleus 1.0 -1.0 CREB1 1.0 -1.0 CREM 1.0 -1.0 NFATC2 1.0 -1.0 NFATC1 1.0 -1.0 IRF8 1.0 -1.0 STAT1 1.0 -1.0 STAT3 1.0 -1.0 STAT5A; STAT5B 1.0 -1.0 STAT6 1.0 -1.0 SOCS1 1.0 -1.0 ODC1 1.0 -1.0 ELK1 1.0 -1.0 MYC 1.0 -1.0 CEBPB 1.0 -1.0 CEBPD 1.0 -1.0 SP1 1.0 -1.0 NFKBIA;NFKBIB; NFKBIE 1.0 -1.0 RELA;REL;NFKB1; RELB;NFKB2 1.0 -1.0 ATF2 1.0 -1.0 **Regulation of gene expression 1.0 -1.0 **Inhibition of gene expression 1.0 -1.0 FOS 1.0 -1.0 JUN 1.0 -1.0 FOSL1 1.0 -1.0 STAT4